Alfredo Quiñones-Hinojosa, M.D., from the department of neurosurgery at Johns Hopkins University, will present "Bridging the Gap in the Fight Against Brain Cancer: From the Operating Room to the Laboratory."
Glioblastoma is the most common primary malignancy of the central nervous system, with a median survival of 14 months. These tumors represent a relentless disease state, and the tumor cells tend to migrate and invade surrounding tissues. These tumors are refractory to combinatorial surgical resection, radiation and chemotherapy.
Increasing evidence suggests that small subsets of cells, called brain tumor stem cells, retain tumor-initiating capacity and are responsible for the invasive and chemoresistant and radioresistant nature of malignant gliomas. In our laboratory we have focused on mechanisms of stem cell migration as well as cell-based delivery of viral and non-viral (nanotechnology) treatments. As we have begun to understand the mechanisms of cancer migration, novel advances in both understanding cell migration and therapeutic approaches will help our efforts to treat this devastating and incurable disease.
Following the lecture, Quiñones-Hinojosa's recent autobiography "Becoming Dr. Q: My Journey from Migrant Farm Worker to Brain Surgeon" will be available for purchase, and "Dr. Q" will sign copies.