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May 23, 2013
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      Oro Valley Councilman Mike Zinkin is looking to clear his name after comments made earlier this month by Mayor Satish Hiremath regarding the c…

      • posted: May 22
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  1. article (May 20) Today's Top Headlines- Boeing Dreamliners get back in the air

    Monday, May 20, 2013 10:06 am

    According to an NBC News report, after 123 days being grounded and then repaired to ensure its battery systems do not catch fire, Boeing 787 Dreamliners are about to once again make commercial flight in the United States. A United Airlines 787 will fly from Houston to Chicago Monday morning carrying more than 250 passengers including the CEO's of United and Boeing.

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  2. article PCC names Lambert new Chancellor

    Friday, May 17, 2013 3:36 pm

    Veteran community college leader Lee D. Lambert today was named chancellor of Pima Community College.

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  3. article Your Weight Matters: Take the Pledge to Talk to a Healthcare Provider

    Wednesday, May 15, 2013 10:19 am

    (NewsUSA) - Five to 10 percent.

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  4. article An Inside Look At Protecting Your Family And Belongings

    Wednesday, May 15, 2013 4:44 am

    (NAPSI)—Staying safe at home can be simpler for you and your family if you heed a few hints from personal security expert Robert Siciliano, CEO of ID Theft Security, and private investigator Robin Martinelli, of Martinelli Investigations Inc.

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  5. article What Every Woman Should Know About Long-Term Care

    Friday, May 10, 2013 11:53 am

    (NewsUSA) - With women generally outliving men, planning for long-term care becomes more urgent for them in their pre-retirement years. After all, while longevity definitely has its upside -- including more time to enjoy travel and family -- there's no denying its biggest potential downside: the increased risk of health problems that can make caring for oneself difficult.

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  6. article (May 10) Today's Top Headlines - Senator McCain looks to decrease cable bills

    Friday, May 10, 2013 11:41 am

    Arizona Sen. John McCain introduced a new bill, the Television Consumer Freedom Act, that let the customers choose the channels in their subscription. 

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  7. article Improving Brain Research for Better Alzheimer's Diagnoses

    Friday, May 10, 2013 11:35 am

    (NewsUSA) - More than 5 million Americans live with Alzheimer's disease -- a number that's only going to rise as more adults age into their mid to late 60s. So, making strides to better understand the disease is a must.

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  8. article Oro Valley earns third “Playful City USA” designation

    Friday, May 10, 2013 4:00 am

    For the third consecutive year, the Town of Oro Valley has earned the “Playful City USA” designation from national non-profit KaBOOM! Presented by The Humana Foundation, Playful City USA is a national program advocating for local policies that increase play opportunities for children and is a key platform in combating the play deficit.

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  9. article The Sweet Truth Behind Honey

    Thursday, May 9, 2013 4:44 am

    (NAPSI)How much do you know about the honey bear bottle in your pantry? With recent confusion over pollen and filtration, the National Honey Board (NHB) wants to clarify any misconceptions surrounding this natural ingredient with harvesting, filtration and nutrition facts about honey. With more than 300 varietals of honey in the United States, honey adds its own unique profile to every recipe. Plus, honey has many benefits before and after it gets to the pantry.

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  10. article Early Detection Of Breast Cancer: Something To Really Like

    Thursday, May 9, 2013 4:44 am

    (NAPSI)We all reflect on how the women in our lives are so important to us and our families. FUJIFILM Medical Systems U.S.A., Inc. and the National Breast Cancer Foundation are working together to raise awareness and encourage all women to understand the importance of early detection of breast cancer. The partnership recently launched Images of Health, a campaign designed to provide educational resources and support for breast cancer patients, survivors and their loved ones.

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  11. article How Your Mattress May Affect Your Relationship

    Thursday, May 9, 2013 4:44 am

    (NAPSI)—Many couples’ romantic problems may be easier to solve than they think. That’s because the trouble, if it’s an intimacy issue, may be due to nothing more than their mattress.

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  12. article How to Customize Offers, Get the Most Out of Daily Deals

    Wednesday, May 8, 2013 10:44 am

    (NewsUSA) - Daily deal sites exploded following the success of sites like Groupon and Living Social, and the multitude of options for discounts has left many consumers overwhelmed.

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  13. article Genetically Modified Salmon Making Progress in Regulatory Review

    Wednesday, May 8, 2013 8:46 am

    (NewsUSA) - After 18 years spent leaping over regulatory hurdles and sputtering in political gridlock, the first genetically modified animal intended for human consumption is one critical step closer to receiving federal approval.

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  14. article Discount Retailer Plans Hiring Events

    Monday, May 6, 2013 9:28 am

    (NewsUSA) - The Bureau of Labor Statistics recently reported the addition of 165,000 jobs in April and a national unemployment average of 7.5 percent. Compared to the nine and 10 percent unemployment rates of 2010, the figure is promising. This May, however, could be a different story as employers typically increase hiring efforts in advance of the summer and holiday seasons.

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  15. article How to be the buyer every seller wants to deal with

    Sunday, May 5, 2013 10:00 pm

    (BPT) - For years, the real estate market has been a buyer’s world, with ample inventory, fewer qualified buyers, and highly motivated (read: desperate) sellers. This spring, some signs are pointing to a shift back toward a seller’s market. If you’re shopping for a home this spring and summer, chances are you’ll face increased competition from other buyers.

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  16. article Organ donation: gift of a second chance at life

    Thursday, May 2, 2013 10:00 pm

    (BPT) - While organ transplantation is a remarkable story in the history of medicine, the need for organs is vastly greater than the number available for transplantation.

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  17. article What's Up UA? - UA Commencement Returns to Arizona Stadium May 10

    Thursday, May 2, 2013 10:30 am

    For the first time in more than 40 years, graduating University of Arizona Wildcats will gather at Arizona Stadium to celebrate their transition from hardworking students to proud alumni.

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  18. article America's Top Charity Influencer

    Thursday, May 2, 2013 4:44 am

    (NAPSI)—It may come as a surprise to some, but the famous face that can encourage people to donate to charity more than any other is that of the First Lady.

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  19. article Gifts That Heal

    Thursday, May 2, 2013 4:44 am

    (NAPSI)—You can show a woman you care by giving a gift that heals. Here’s how:

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  20. article Are Women Better Leaders than Men?

    Wednesday, May 1, 2013 10:00 pm

    (StatePoint) With more women rising to top positions in business and government, the topic of women and their capacity for leadership has been all the buzz in the media lately.

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  21. article Making Headway Against Traumatic Brain Injuries

    Wednesday, May 1, 2013 12:51 pm

    (NewsUSA) - Despite the prevalence of traumatic brain injuries (TBIs) and concussions among athletes and service members, the road to diagnosis and prevention is an unpaved one riddled with obstacles.

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  22. article More than 400 attend Marana State of the Town

    Wednesday, May 1, 2013 4:00 am

    During the annual State of the Town Address on April 26, Marana Mayor Ed Honea said Marana will continue to stay true to its core mission, which is devoted to strong public infrastructure, public safety and public services.

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  23. article 5 Tips To Recruit Top Talent

    Thursday, April 25, 2013 4:44 am

    (NAPSI)—Here’s a smart way for entrepreneurs to be successful—and save time and money: Learn from the mistakes of others.

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  24. article Foothills Club of Tucson selects new executive director

    Tuesday, April 23, 2013 2:53 pm

    The Foothills Club of Tucson, a local 501(c)(3)non-profit, charitable organization of local business and civic leaders, has selected veteran non-profit manager ARTIE STONE as Executive Director. Stone is the past President and CEO of Craig Snow & Associates, an association management company working with non-profits, governments and other entities in strategic planning, fundraising and implementation of events. Most recently Stone was with the Arizona Blind & Deaf Children’s Foundation. He replaces Leslie Hargrove who is relocating to Colorado Springs with her husband Steven Hargrove.

  25. article What's Up UA? - UA Spin-Off to Test Cancer-Preventing Drug Combination

    Tuesday, April 23, 2013 9:38 am

    Cancer Prevention Pharmaceuticals, Inc., or CPP, has helped launch a phase-III clinical trial to test the efficacy of a combination drug that has shown promise of preventing colon cancer. CPP was founded in 2008 to apply decades' worth of systematic, basic research led by University of Arizona professor emeritus Eugene Gerner and former UA researcher Frank Meyskens to improve clinical practice. 

    During the trial, which is funded by the National Cancer Institute, 1,340 colon cancer survivors will receive daily treatment for three years to prevent the occurrence of colorectal cancer or high-risk polyps and compare the effects to a placebo group. 
     
    "Our long-term vision is to change the status quo from treating and managing cancer to intervening before cancer manifests and prevent it altogether," said Jeffrey Jacob, founding CEO of Cancer Prevention Pharmaceuticals. "The idea is just like in the approach to heart disease: Instead of waiting for heart attack or stroke to happen, we give patients cholesterol-lowering or blood pressure-lowering medicine to prevent those events from happening in the first place."
     
    In addition to colorectal cancer, the same treatment approach has shown promise in preventing prostate, skin and possibly other cancers as well. Colorectal cancer affects about 1 million people in the U.S., Jacob said. 
     
    "Our two-drug-combination targets different pathways that are important in cancer development," explained CPP co-founder Eugene Gerner, who retired from the department of cellular and molecular medicine in the UA College of Medicine last year. "Over years of research using cell cultures and mouse models in the lab, we have been able to systematically elucidate the molecular pathways underlying cancer formation and how to target them with those drugs."
     
    This work then was successfully translated to the clinic with the help of the NCI and various research partners.  
     
    One, Sulindac, belongs to of the class of non-steroidal anti-inflammatory drugs, with aspirin being a notable member. Sulindac targets the inflammatory pathway. The other, called Eflornithine, homes in on the  polyamine pathway. Driven by growth factors, this pathway is essential in stimulating growth and development in most living organisms.
     
    In his research, which has been continuously funded by the NCI since 1975, Gerner collaborated closely with Meyskens, who was a professor of medicine at the UA College of Medicine before he moved to University of California, Irvine. Both were members of the Arizona Cancer Center. Even as professor emeritus, Gerner still does research in his lab at the UA and is an active member of the UA's BIO5 Institute. 
     
    Gerner said his group focused on colon cancer in the 1980s because it was the one frequent type of human cancer for which a substantial amount of genetic information became available, especially with the Human Genome Project.
     
    "Our approach strictly focuses on the biological mechanisms and the genetics," Gerner said. "I came to the UA in 1974 and initially worked in cancer therapeutics. By the mid 1980s, I was discouraged by the lack of progress that was being made at the time. So we set out to understand the underlying processes that lead to cancer, such as the roles of various growth factors and cancer-promoting genes. 
     
    According to Jacob, the company's current focus is on intervening with patients facing elevated risk, including cancer survivors or individuals with a genetic predisposition, with the ultimate goal of expand the same approach to other forms of cancer and the general at-risk population. 
     
    Gerner said that many experts estimate at least 70 percent of colorectal cancer are associated with risk factors such as weight gain and a diet high in fat and beef but low in fiber. 
     
    "However, there are a substantial number of individuals who eat perfect diets and exercise, but still face a risk from mutations that arise spontaneously or they inherited," he said. 
     
    "Our drugs are targeting growth and inflammatory pathways leading to the synthesis of polyamines, but diets contain polyamines also. Our company is looking at ways to manage overall risk, including diet, genetic factors and exercise."
     
    In other clinical trials, CPP is also testing the therapy on people with known genetic predispositions to colorectal cancer such as patients with Familial Adenomatous Polyposis, a genetic disease that comes with a nearly 100 percent risk of developing colon cancer before age 40. 
     
    "The only option for most people with FAP is to remove the entire colon in their late teens or early twenties," Gerner said, "and they still face a lifetime of surgeries to control the condition."
     
    Neuroblastoma, a pediatric cancer and the second leading killer of children with cancer, according to Jacob, is another avenue the company is pursuing in a clinical trial. 
     
    In addition to drug therapies, CPP is considering partnerships with food companies to develop certain types of "functional foods" or "medical foods" that would exploit the same science to reduce cancer risk in certain demographics. The company is also developing new diagnostic approaches to identify people who are at higher risk for cancer who could ultimately benefit from specific therapies or medical foods. 
     
    "Part of our ability to reduce risk is having means to assess that risk and evaluate the effectiveness of drugs we are using," Gerner added. "For example, some drugs work better in some people than in others. The goal is to develop diagnostics that tell us about an individual's susceptibility."
     
    David Alberts, director of the UA's Arizona Cancer Center, said: "Gene Gerner and Frank Meyskens, both absolutely brilliant scientists, have transformed exciting laboratory research findings into medications that have the great potential of saving hundreds of thousands of lives. We are very proud that the University of Arizona Cancer Center served as the incubator for this powerful, new chemoprevention technology for colorectal cancer and treatment for recurrent neuroblastoma."
     

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Sunshine School in Oro Valley read more

Sunshine School 9000 N. Oracle Road Tucson, AZ 85704, Suite 204 (520)742-6874 www.sunshineschooltucson.org/

Sunshine School in Oro Valley

Sunshine School 9000 N. Oracle Road Tucson, AZ 85704, Suite 204 (520)742-6874 www.sunshineschoolt...

Northwest Chatter

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Baby in stroller Falls Into Train Tracks Mom Jumps In Before Train Barrels In Caught On Camera read more

Baby in stroller Falls Into Train Tracks Mom Jumps In Before Train Barrels In Caught On Camera. A stroller carrying a 14-month-old girl rolled off a slanted train station platform and fell onto the tracks Wednesday, but the girl's mother leaped onto the tracks to rescue her with the help other passengers, transit officials said."What it looks like to us is that the mother became distracted by something, didn't apply the brake on the stroller and the stroller was able to move off the platform and onto the tracks," said Scott Sauer, director of system safety for the Southeastern Pennsylvania Transportation Authority. The accident happened Wednesday afternoon at the 56th Street station of the Market-Frankford Line in west Philadelphia. The platform at the station is slanted slightly for drainage purposes, Sauer said.Surveillance video shows a woman on the eastbound platform with the girl in a jogging stroller, which slowly rolls forward and topples over onto the tracks about 5 feet below. What initially appears to be the girl flying out of the stroller apparently was just a towel or a bag. The stroller comes to rest on the outer rail, which carries no charge. The woman is seen jumping down and lifting the girl to a man waiting on the platform. Other passengers ran to help, and one used an emergency call box to alert SEPTA police, who held an incoming train at the preceding stop.The infant was taken to Children's Hospital of Philadelphia for treatment of a cut on her forehead. Sauer said during a news conference that watching the video was "gut-wrenching.""With the stroller moving at such a slow rate of speed, you know, you want to call out to someone, `Hey, the stroller's moving! Somebody grab the stroller,'" Sauer said. He said the line is one of SEPTA's busiest, with trains running every six to 10 minutes. SEPTA police said no charges will be filed but the accident serves as a reminder for other riders to lock stroller brakes when waiting on platforms.

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