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May 18, 2013
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Displaying results 1 - 25 of 14 for gaining weight in college. Subscribe to this search

  1. article What's Up UA? - UA Spin-Off to Test Cancer-Preventing Drug Combination

    Tuesday, April 23, 2013 9:38 am

    Cancer Prevention Pharmaceuticals, Inc., or CPP, has helped launch a phase-III clinical trial to test the efficacy of a combination drug that has shown promise of preventing colon cancer. CPP was founded in 2008 to apply decades' worth of systematic, basic research led by University of Arizona professor emeritus Eugene Gerner and former UA researcher Frank Meyskens to improve clinical practice. 

    During the trial, which is funded by the National Cancer Institute, 1,340 colon cancer survivors will receive daily treatment for three years to prevent the occurrence of colorectal cancer or high-risk polyps and compare the effects to a placebo group. 
     
    "Our long-term vision is to change the status quo from treating and managing cancer to intervening before cancer manifests and prevent it altogether," said Jeffrey Jacob, founding CEO of Cancer Prevention Pharmaceuticals. "The idea is just like in the approach to heart disease: Instead of waiting for heart attack or stroke to happen, we give patients cholesterol-lowering or blood pressure-lowering medicine to prevent those events from happening in the first place."
     
    In addition to colorectal cancer, the same treatment approach has shown promise in preventing prostate, skin and possibly other cancers as well. Colorectal cancer affects about 1 million people in the U.S., Jacob said. 
     
    "Our two-drug-combination targets different pathways that are important in cancer development," explained CPP co-founder Eugene Gerner, who retired from the department of cellular and molecular medicine in the UA College of Medicine last year. "Over years of research using cell cultures and mouse models in the lab, we have been able to systematically elucidate the molecular pathways underlying cancer formation and how to target them with those drugs."
     
    This work then was successfully translated to the clinic with the help of the NCI and various research partners.  
     
    One, Sulindac, belongs to of the class of non-steroidal anti-inflammatory drugs, with aspirin being a notable member. Sulindac targets the inflammatory pathway. The other, called Eflornithine, homes in on the  polyamine pathway. Driven by growth factors, this pathway is essential in stimulating growth and development in most living organisms.
     
    In his research, which has been continuously funded by the NCI since 1975, Gerner collaborated closely with Meyskens, who was a professor of medicine at the UA College of Medicine before he moved to University of California, Irvine. Both were members of the Arizona Cancer Center. Even as professor emeritus, Gerner still does research in his lab at the UA and is an active member of the UA's BIO5 Institute. 
     
    Gerner said his group focused on colon cancer in the 1980s because it was the one frequent type of human cancer for which a substantial amount of genetic information became available, especially with the Human Genome Project.
     
    "Our approach strictly focuses on the biological mechanisms and the genetics," Gerner said. "I came to the UA in 1974 and initially worked in cancer therapeutics. By the mid 1980s, I was discouraged by the lack of progress that was being made at the time. So we set out to understand the underlying processes that lead to cancer, such as the roles of various growth factors and cancer-promoting genes. 
     
    According to Jacob, the company's current focus is on intervening with patients facing elevated risk, including cancer survivors or individuals with a genetic predisposition, with the ultimate goal of expand the same approach to other forms of cancer and the general at-risk population. 
     
    Gerner said that many experts estimate at least 70 percent of colorectal cancer are associated with risk factors such as weight gain and a diet high in fat and beef but low in fiber. 
     
    "However, there are a substantial number of individuals who eat perfect diets and exercise, but still face a risk from mutations that arise spontaneously or they inherited," he said. 
     
    "Our drugs are targeting growth and inflammatory pathways leading to the synthesis of polyamines, but diets contain polyamines also. Our company is looking at ways to manage overall risk, including diet, genetic factors and exercise."
     
    In other clinical trials, CPP is also testing the therapy on people with known genetic predispositions to colorectal cancer such as patients with Familial Adenomatous Polyposis, a genetic disease that comes with a nearly 100 percent risk of developing colon cancer before age 40. 
     
    "The only option for most people with FAP is to remove the entire colon in their late teens or early twenties," Gerner said, "and they still face a lifetime of surgeries to control the condition."
     
    Neuroblastoma, a pediatric cancer and the second leading killer of children with cancer, according to Jacob, is another avenue the company is pursuing in a clinical trial. 
     
    In addition to drug therapies, CPP is considering partnerships with food companies to develop certain types of "functional foods" or "medical foods" that would exploit the same science to reduce cancer risk in certain demographics. The company is also developing new diagnostic approaches to identify people who are at higher risk for cancer who could ultimately benefit from specific therapies or medical foods. 
     
    "Part of our ability to reduce risk is having means to assess that risk and evaluate the effectiveness of drugs we are using," Gerner added. "For example, some drugs work better in some people than in others. The goal is to develop diagnostics that tell us about an individual's susceptibility."
     
    David Alberts, director of the UA's Arizona Cancer Center, said: "Gene Gerner and Frank Meyskens, both absolutely brilliant scientists, have transformed exciting laboratory research findings into medications that have the great potential of saving hundreds of thousands of lives. We are very proud that the University of Arizona Cancer Center served as the incubator for this powerful, new chemoprevention technology for colorectal cancer and treatment for recurrent neuroblastoma."
     

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  2. article PCC Track & Field Teams Compete in Phoenix

    Monday, January 21, 2013 10:08 am

     The Pima Community College men’s and women’s track & field teams competed in their first indoor meet of the 2013 season at Paradise Valley Community College on Saturday.

  3. article Sunbelt Collegiate - Getting mean on the Freshman 15

    Thursday, August 9, 2012 3:11 pm

    In the wake of the 2012 London Olympics, we've all realized how terribly out of shape we are. Paired with the prospect of returning to school in the coming weeks,

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  4. article Fitness Challenge - Catherine Reynolds

    Sunday, August 5, 2012 9:50 am

    I’m so close, folks! During a faux weigh-in last week, I weighed in at only 3.5 pounds higher than what I weighed in college! That’s pre-marriage, pre-baby, pre-twenties! Not to mention, people are starting to comment regularly on the fact that I’ve lost lots of weight.

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  5. article From CDO to MLB, Kinsler thriving

    Wednesday, January 11, 2012 4:00 am

    Canyon Del Oro High School has a long reputation of sending its baseball players to the Majors. In total, seven players out of CDO have advanced to play in the MLB, one of which played in the 2011 World Series with the Texas Rangers.

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  6. article Winners prepare for a yearlong Anytime Fitness Challenge

    Wednesday, December 21, 2011 4:00 am

    In 2012, six residents from Oro Valley and Marana have received an opportunity worth $3,500 to become healthier, fit and meet life goals through the Anytime Fitness challenge.

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  7. article The Guide

    Wednesday, May 11, 2011 3:00 am

    MOVIES

  8. article Nighthawk grid coach Gary Minor resigns post to make personal time

    Tuesday, February 17, 2009 12:00 am

    Northwest prep football fans must be wondering what hit them.

  9. article The hard knock life

    Tuesday, October 7, 2008 11:00 pm

    Throwing footballs never led George Roop to a scholarship, so the former Canyon Del Oro quarterback switched gears and cracked the junior college books.

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  10. article Ultimately, Dems have the biggest problems

    Tuesday, June 17, 2008 11:00 pm

    I have ranted on numerous occasions against my own party, noting the three “C”s that currently grip too much of it and stain its brand: cluelessness, cowardice and corruption. Too many Republicans are either unable to grasp or too craven to admit they have abandoned the principles of limited government that got them elected and are into denial over the damage done by a steady cavalcade of crooks and perverts.

  11. article Northwest schools fare well in contests of mental prowess

    Wednesday, March 29, 2006 12:00 am

    March 29, 2006 - Northwest schools are quickly proving the area is raising some of the brightest students in the country.

  12. article The Sporting Life: Moore strength than most

    Wednesday, March 15, 2006 12:00 am

    March 15, 2006 - When Dan Moore walks the halls of Mountain View High School, no one knocks the books from his hand, places "kick me" signs on his back or even dares look at him cross.

  13. article CONFLICT OF INTEREST: THE CHIEF AND THE NEW WEST

    Wednesday, January 16, 2002 12:00 am

    The odds were stacked against Westyn Lee Tanawa Hamilton when he squared off against five bouncers behind the New West/Gotham nightclub in the cold, early morning hours of Jan. 2, 2000.

  14. article TALE OF TWO TIGERS

    Tuesday, August 28, 2001 11:00 pm

    The similarities between Dusty Alexander and Clay Hardt seem to end at their Marana High School diplomas.

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