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June 19, 2013
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      As Oro Valley Safeway Manager Mike Hennings prepares for retirement after 42 years with the company, he says the career is all he’s ever known.

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  1. article What's Up UA? - $6M Grant Boosts Molecular Heart Research

    Wednesday, June 19, 2013 1:00 pm

    A $6 million grant from Fondation Leducq, a French non-profit health research foundation fostering international efforts to combat cardiovascular disease, will boost an interdisciplinary, collaborative push to better understand how the heart deals with mechanical stress under healthy conditions and in the case of a defect. 
     
    Henk Granzier, a professor in the department of physiology and the Molecular Cardiovascular Research Program at the University of ArizonaCollege of Medicine, is one of two principal investigators leading the project, which was awarded as a transatlantic network grant, connecting scientists from seven institutions in Europe and the U.S. 
     
    "Many networks compete for this grant, and it is a great honor to be one of the very few that were selected for funding," said Granzier, who will oversee all projects, coordinate and communicate with the network collaborators and assist designing experiments, analyzing data and publishing scientific results. 
     
    The research endeavor revolves around titin, a protein that acts as a "molecular spring" and plays important roles in how muscle cells register mechanical stress (see UANews story, "UA Researcher Studies Protein's Link to Heart Disease"). Titin has moved into the spotlight of cardiovascular research once it was found that mutations in the titin gene are involved in many heart defects.
     
    "With this project, we want to try and understand the interplay between mechanical stress and heart disease, and how titin factors into all of that," said Granzier, who is also a member of the UA BIO5 Institute and holds the Allan and Alfie Norville Endowed Chair for Heart Disease in Women Research at the UA's Sarver Heart Center. 
     
    "You have billions of titin molecules in your heart, where they help it contract and expand," he said. "Titin is very important to make sure your heart doesn't expand too much or too little, so it doesn't overfill or under-fill with blood."
     
    But the molecule, which occurs not only in heart muscle but skeletal muscle as well, does much more than that. 
     
    "Titin acts as a sensor enabling a heart muscle cell to measure mechanical stress," Granzier explained. "When you lift weights, titin senses the added load and interacts with proteins that trigger signaling cascades, which in turn activate genes to crank out more muscle material, so your muscles become bulkier."
     
    Scientists hope that once they better understand the processes at a molecular level, they can develop therapies for conditions that are untreatable now. 
     
    "A big goal of this grant is to understand how mutations in titin cause pathological changes," Granzier said. "We'll focus largely on titin and all the proteins that interact with it. So far, we know of more than 20."
     
    For example, one particular mutation in the titin gene is known to cause a disease called ARVC, or arrhythmogenic right ventricular cardiomyopathy, an inherited heart muscle disorder where damaged heart muscle is gradually replaced by non-muscle tissue. 
     
    "This particular mutation makes titin more susceptible to breaking down," Granzier said. "Others truncate the protein so it loses pieces of its functionality."
     
    BIO5's Genetically Engineered Mouse Models (GEMM) Core, directed by Tom Doetschman, developed a mouse model allowing Granzier to study the mechanisms that underlie this disease. 
     
    "We genetically engineered this mutation to replicate the human disease in the mouse heart, and then we study the mouse to tease apart the disease mechanism under controlled conditions," Granzier said.
     
    A different series of genetic alterations in titin's DNA sequence was found to be the causal defect in about one third of individuals afflicted with a condition called dilated cardiomyopathy – another form of heart failure. Affected individuals frequently develop severe heart failure in their 30s or 40s.
     
    "We want to study this in this grant as well," said Granzier. "How do the mutations lead to the diseased heart?"
     
    To find answers, Granzier and his colleagues apply mouse genetics to eliminate certain titin-binding proteins and see how that changes the sensing and the enlargement of the heart.
     
    "What we want to know is, 'If you have a certain titin binding partner missing, how does the system respond and possibly cause diseases?'" Granzier said, adding that the six diseases that have so far been linked to titin are likely only the tip of an iceberg.
     
    "As more and more high-throughput sequencing technologies become available, my guess is we will find many more diseases that involve titin," he added. "And as awareness of these defects increases, it will become possible to screen family members for such mutations."
     
    Granzier's lab has established a worldwide reputation in titin research by studying the protein and its interactions at every scale, from the individual molecule to the entire heart.
     
    Using an atomic force microscope, the group can make measurements on single titin molecules.
     
    "We can measure characteristics like strength and elasticity of the molecule, and how those are affected by mutations in the titin gene," Ganzier explained. "We also study the mechanics of single cells isolated from the heart. And we can genetically alter the titin gene, take out pieces or add pieces to it, to mimic the mutations that we know exist in patients."
     
    Through these studies, the group discovered that the mutations that causes ARVC weakens the molecule, causing the "spring structure" to unfold. 
     
    "Normally the molecule folds into domains," Granzier said. "It resembles a string of pearls, and when you stretch the molecule, the pearls line up and you pull them taut. But if you have a mutation, it weakens the structure of the domains. The pearls unravel and once the molecule starts breaking down, the mechanical sensing ability is destroyed and the elasticity is messed up."
     
    Although therapies might not become available for a while, knowing what causes the trouble is a critically important first step, Granzier pointed out.
     
    Some day, therapeutics could be developed that interact with the weak spot in the mutated titin molecule and make it stronger. Another approach, currently tested for muscular dystrophy, involves drugs homing in on the machinery inside the cell that manufactures the protein from its genetic blueprint, instructing it to skip the mutated parts. 
     
    "Once we understand the sensing mechanisms of titin and how they are affected by mutations, we could ultimately come up with drugs that lessen the impact of the disease or prevent it altogether," Granzier said.
     
    Under the network grant, the collaboration will exchange expertise, reagents, genetically modified mouse models and researchers to maximize collaboration and results and tackle all aspects of these diseases. 
     
    "It is a huge honor for Henk and the UA to lead this international, multidisiplinary project from Fondation Leducq to decipher the impact of mutations in contractile proteins on human cardiac myopathies," said Carol Gregorio, who heads the Molecular Cardiovascular Research Program and is a collaborator on the grant. 
     
    In addition to the UA, the main research centers participating on the grant are the University of Heidelberg, Germany; University of California San Diego School of Medicine; National Heart & Lung Institute at the Imperial College London; the University of Liverpool; French biotech company Genethon; and the University of Pennsylvania School of Medicine. 
     

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  2. article Beloved Safeway manager says farewell

    Wednesday, June 19, 2013 4:00 am

    As Oro Valley Safeway Manager Mike Hennings prepares for retirement after 42 years with the company, he says the career is all he’s ever known.

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  3. Flag Day

    Golder Ranch Fire District Honor Guard members Michael Thomas, left, Tom Hemandollar, middle, and Johnny Miller, right, raise the American Flag during the Flag Day ceremony in SaddleBrooke last Friday.

  4. Flag Day

    The Golder Ranch Fire District Honor Guard proceeds to raise a flag during the Flay Day ceremony last week.

  5. article U.S. Rep. Ron Barber votes for strong national defense

    Friday, June 14, 2013 1:15 pm

    U.S. Rep. Ron Barber today joined a strong bipartisan majority of the House in voting to authorize Department of Defense programs and funding that strengthens sexual assault protections for service members, supports security efforts along the Southwest border, provides a pay raise for members of the military and includes robust funding for the Southern Arizona aerospace and defense industries.

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  6. article My two favorite dads

    Wednesday, June 12, 2013 4:00 am

    On Sunday, we will honor all the dads out there for Father’s Day. For many, the dad is overshadowed by mothers but plays such a key role in the growth and development of our children that they should never be forgotten.

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  7. article Allstate teams up with Community Foodbank of Southern Arizona

    Tuesday, June 11, 2013 6:09 pm

    Today Tucson-area Allstate agents and employees teamed up with Community Food Bank of Southern Arizona to sort donated food and ultimately help fight community hunger.

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  8. article PCC awards 16 Practical Nursing certificates June 13

    Tuesday, June 11, 2013 2:24 pm

    Pima Community College’s Center for Training and Development on June 13 will honor 16 students who have earned certificates in the high-demand profession of Practical Nursing.

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  9. article PCC site of community forum on sex trafficking, June 13

    Tuesday, June 11, 2013 11:09 am

    Pima Community College is honored to be the site of a community forum discussing an important topic: sex trafficking.

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  10. article (June 9) Today's Top Headines - The top 10 stories of the day

    Sunday, June 9, 2013 8:21 am

    1. POLICE NAME SUSPECT IN SANTA MONICA SHOOTINGS

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  11. article PCC's Dr. Suzanne L. Miles retires

    Friday, June 7, 2013 10:56 am

    Dr. Suzanne L. Miles, a veteran Pima Community College administrator whose 27 years of service included numerous high-profile posts, has decided to retire.

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  12. article What's Up UA? - Brigetta Barrett Named Pac-12 Woman of the Year

    Thursday, June 6, 2013 9:14 am

    The University of Arizona's Olympic silver medalist high jumper Brigetta Barrett has been named the Pac-12 Conference Woman of the Year for the 2012-13 academic year, Pac-12 Commissioner Larry Scott has announced.

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  13. article Making A Difference For Generations

    Thursday, June 6, 2013 4:44 am

    (NAPSI)—America’s rapidly aging population creates a tremendous opportunity to unleash the power of volunteers on some of the nation’s most pressing problems. Consider this: Baby boomers are the largest, healthiest and best-educated generation in history. Volunteering can be their second act, fulfilling their passions and helping them stay active, healthy and engaged.

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  14. article What's Up UA? - UA Classical Guitar Program Among World’s Best

    Wednesday, June 5, 2013 5:33 pm

    Chilean Master's student Pablo Gonzalez first picked up a classical guitar when he was 8 years old. The Spanish guitar stayed with him through his early education and finally swept him north to the University of Arizona as a Fulbright scholar, where he joined the roughly 25 undergraduate and graduate students in the UA's Bolton Guitar Studies Program.

    "You can find it in almost any home in my country," Gonzalez said of classical guitar music.

    Students in the UA program hail from countries around the world, including France, Chile, Philippines, China, Brazil, Peru, Mexico, Argentina, Norway, Turkey and many others, drawn by the reputation of a music program like no other.

    Many elements of the Bolton guitar program are found in no other classical guitar program in the world such as four endowed guitar competitions supported by the D'Addario string company and by donors, said professorR. Thomas Patterson, who heads the program.

    With boons such as artists in residence David Russell, a world-renowned musician and recording artist, and Grammy Award winners Sérgio and Odair Assad, it may not be surprising that UA classical guitar students regularly win at national and international guitar competitions.

    "The Assad Brothers come for a week in the fall, and David Russell comes for a week in the spring, and they teach for a week and give concerts," said Julia Pernet, chairman of the Tucson Guitar Society. "I think that's a very unusual asset to have, to have that class of performing guitarists come and spend a week, and really know the students."

    Patterson, who joined the UA faculty in 1980, is credited by many for making the guitar program what it is today. "I wanted to make it a flagship, a model for other programs around the country, around the world," Patterson said.

    "If you ask other guitar professors what are their greatest achievements, they say, 'Well, I published this book, or that book,'" said Misael Barraza, a first year Master's student in the program, who recently won theMontreal International Competition. "If you ask Tom, he'll say, 'See this guitar champion, or that champion? This was my student.'"

    "One of the great things that Tom is able to do is assist students to get to these international competitions and to try themselves out against the world," Pernet added.

    "We've seen people make extraordinary moves within our program," said Patterson. "It's exciting to see a high-end person achieve an international prize, but someone who maybe you're taking a risk with, to see them succeed is absolutely amazing."

    Pernet brings world-renowned performing artists to Tucson every year through the Tucson Guitar Society. "Part of the agreement that I sign with them is that they will give master classes for the UA guitar program," she said.

    In 2011, Sanford and Phyllis Bolton, lifelong music lovers and supporters of classical guitar, gave $2 million to establish the Sanford and Phyllis Bolton Endowed Chair for Classical Guitar, a position held by professor Patterson. Shortly after, Bolton gave an additional $1.1 million, establishing the Sanford and Phyllis Bolton Endowment for Guitar. 

    "This was the largest gift of its kind in the history of fine arts," Patterson said, a gift that has enabled the program to support talented students who otherwise may not be able to pursue their dreams with acoustic guitar. In honor of the support, the program changed its name to the Bolton Guitar Studies Program.

    The reputation of the program, its calendar packed with events and activities, and the supportive student community have attracted classical guitar talents from many nations. "I'm here because of the reputation of the guitar program," said Ivar Fojas, who is from the Philippines and also a Fulbright scholar, entering the third year of his doctoral studies.

    "Normally, other guitar programs would have one or two recitals each semester," Fojas said. "We have them every single week. I've learned how to listen, to really be critical of myself."

    "That's really what makes the difference between players," Barraza added. "Is how well you can listen to yourself."

    The guitar program curriculum engages students in the community, with a public performance every Friday at 11 a.m. in the UA Museum of Art, and many other concerts and recitals throughout the year.

    Patterson said he also makes effort to engage the community through concerts and working with children, to get them involved with guitar and music at a young age.

    "It really pushes you to have higher standards for yourself," said Leandra Hubka, who is finishing her Master's degree. "There are so many opportunities to play for the public," she added. "You get better by playing for people."

    Barraza said he aims for a concert career, and that the UA guitar program has "been a huge influence on me. I wouldn't be able to do without it."

    "We have an enormously supportive group of people," Patterson said. "I have friends who have traveled all over the world; I ask them if this happens anywhere else, and they say no."

    "We have four in-house competitions each year," Hubka said. "It would be really easy to get competitive with each other, but we're not at all." Perhaps competition is out of the question among a group of people unified by the sound of an instrument they can't put down.

    "It has that effect sometimes," Barraza mused. "The guitar just grabs onto you, and that's it."

     

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  15. article Congressionally recognized artwork

    Wednesday, June 5, 2013 4:00 am

    On May 31, at the Oro Valley Public Library, U.S. Rep. Ann Kirkpatrick, D-Ariz., formally announced the winners of the Congressional Art Competition for District 1.

    7 images

  16. article ‘Now You See Me’ is a strong summer hit

    Wednesday, June 5, 2013 4:00 am

    While Will Smith’s “After Earth” seemed to attract many of the headlines going into the weekend’s movie Box Office openings, it was “Now You See Me” that came in second behind the summer hit “Fast and Furious 6”.

    1 image 1 youtube

  17. Congressional Art Competition

    U.S. Rep. Ann Kirkpatrick, D-Ariz. honors Ironwood Ridge High School graduate Stephanie Spalding at the Oro Valley Public Library last week.

  18. Congressional Art Competition

    U.S. Rep. Ann Kirkpatrick, D-Ariz. honors Ironwood Ridge High School graduate Stephanie Spalding at the Oro Valley Public Library last week.

  19. article (June 2) Today's Top Headlines - Justin Bieber's popularity continues to shrink

    Sunday, June 2, 2013 9:06 am

    According to a TODAY contributor, there was a time when booing Justin Bieber seemed unthinkable, but that’s just what happened at the Billboard Music Awards May 19 when the 19-year-old accepted the first-ever Milestone Award, given to honor the “ingenuity of this year’s hitmakers.”

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  20. article Encourage Kids to Have Gadget-Free Fun this Summer

    Friday, May 31, 2013 9:41 am

    (StatePoint) You may remember your parents telling you to turn off the television and go outside or read a book. But these days, it’s harder than ever to separate kids from media devices, especially as their options become more mobile.

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  21. article Alberding Amble raises $1,360 for PCC math scholarships

    Thursday, May 30, 2013 12:15 pm

    Four Pima Community College students have been awarded Art Alberding Math Scholar Awards for 2013-14.

    1 image

  22. article Pet News - Free adult cats in June for national Adopt-a-Shelter-Cat Month

    Thursday, May 30, 2013 10:00 am

    Every year about this time, the cat adoption room at Pima Animal Care Center is flooded with kittens, leaving lots of kitties in need of new homes. 

  23. PRCA Graduation

    Valedictorian Jared Hout giving his speech with Josh Tvrdy patiently waiting his turn Honor the parents of the seniors.

  24. article Giving back to family caregivers: Tips to help those who sacrifice for others

    Monday, May 27, 2013 5:00 pm

    (BPT) - No one knows exactly what life will bring, but we all know that there will be joys and there will be challenges. Sometimes, life gives you a combination – as millions of average Americans who are family caregivers can attest. Providing dedicated care to a loved one is a generous way to live one’s life, but it can also brings difficulties, stress and isolation. That’s why giving back to those unsung heroes – caregivers – who give so much can make a world of difference to them, and the people they help.

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  25. article Hundreds of motorcyclers stop in Marana on their way to Washington D.C. for Memorial Day

    Monday, May 27, 2013 8:45 am

    Hundreds of motorcyclists riding on behalf of Run for the Wall made their way through Marana on May 17.

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