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June 19, 2013
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    • Beloved Safeway manager says farewell

      As Oro Valley Safeway Manager Mike Hennings prepares for retirement after 42 years with the company, he says the career is all he’s ever known.

      • posted: June 19
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Displaying results 1 - 25 of 1301 for prevention. Subscribe to this search

  1. article What's Up UA? - $6M Grant Boosts Molecular Heart Research

    Wednesday, June 19, 2013 1:00 pm

    A $6 million grant from Fondation Leducq, a French non-profit health research foundation fostering international efforts to combat cardiovascular disease, will boost an interdisciplinary, collaborative push to better understand how the heart deals with mechanical stress under healthy conditions and in the case of a defect. 
     
    Henk Granzier, a professor in the department of physiology and the Molecular Cardiovascular Research Program at the University of ArizonaCollege of Medicine, is one of two principal investigators leading the project, which was awarded as a transatlantic network grant, connecting scientists from seven institutions in Europe and the U.S. 
     
    "Many networks compete for this grant, and it is a great honor to be one of the very few that were selected for funding," said Granzier, who will oversee all projects, coordinate and communicate with the network collaborators and assist designing experiments, analyzing data and publishing scientific results. 
     
    The research endeavor revolves around titin, a protein that acts as a "molecular spring" and plays important roles in how muscle cells register mechanical stress (see UANews story, "UA Researcher Studies Protein's Link to Heart Disease"). Titin has moved into the spotlight of cardiovascular research once it was found that mutations in the titin gene are involved in many heart defects.
     
    "With this project, we want to try and understand the interplay between mechanical stress and heart disease, and how titin factors into all of that," said Granzier, who is also a member of the UA BIO5 Institute and holds the Allan and Alfie Norville Endowed Chair for Heart Disease in Women Research at the UA's Sarver Heart Center. 
     
    "You have billions of titin molecules in your heart, where they help it contract and expand," he said. "Titin is very important to make sure your heart doesn't expand too much or too little, so it doesn't overfill or under-fill with blood."
     
    But the molecule, which occurs not only in heart muscle but skeletal muscle as well, does much more than that. 
     
    "Titin acts as a sensor enabling a heart muscle cell to measure mechanical stress," Granzier explained. "When you lift weights, titin senses the added load and interacts with proteins that trigger signaling cascades, which in turn activate genes to crank out more muscle material, so your muscles become bulkier."
     
    Scientists hope that once they better understand the processes at a molecular level, they can develop therapies for conditions that are untreatable now. 
     
    "A big goal of this grant is to understand how mutations in titin cause pathological changes," Granzier said. "We'll focus largely on titin and all the proteins that interact with it. So far, we know of more than 20."
     
    For example, one particular mutation in the titin gene is known to cause a disease called ARVC, or arrhythmogenic right ventricular cardiomyopathy, an inherited heart muscle disorder where damaged heart muscle is gradually replaced by non-muscle tissue. 
     
    "This particular mutation makes titin more susceptible to breaking down," Granzier said. "Others truncate the protein so it loses pieces of its functionality."
     
    BIO5's Genetically Engineered Mouse Models (GEMM) Core, directed by Tom Doetschman, developed a mouse model allowing Granzier to study the mechanisms that underlie this disease. 
     
    "We genetically engineered this mutation to replicate the human disease in the mouse heart, and then we study the mouse to tease apart the disease mechanism under controlled conditions," Granzier said.
     
    A different series of genetic alterations in titin's DNA sequence was found to be the causal defect in about one third of individuals afflicted with a condition called dilated cardiomyopathy – another form of heart failure. Affected individuals frequently develop severe heart failure in their 30s or 40s.
     
    "We want to study this in this grant as well," said Granzier. "How do the mutations lead to the diseased heart?"
     
    To find answers, Granzier and his colleagues apply mouse genetics to eliminate certain titin-binding proteins and see how that changes the sensing and the enlargement of the heart.
     
    "What we want to know is, 'If you have a certain titin binding partner missing, how does the system respond and possibly cause diseases?'" Granzier said, adding that the six diseases that have so far been linked to titin are likely only the tip of an iceberg.
     
    "As more and more high-throughput sequencing technologies become available, my guess is we will find many more diseases that involve titin," he added. "And as awareness of these defects increases, it will become possible to screen family members for such mutations."
     
    Granzier's lab has established a worldwide reputation in titin research by studying the protein and its interactions at every scale, from the individual molecule to the entire heart.
     
    Using an atomic force microscope, the group can make measurements on single titin molecules.
     
    "We can measure characteristics like strength and elasticity of the molecule, and how those are affected by mutations in the titin gene," Ganzier explained. "We also study the mechanics of single cells isolated from the heart. And we can genetically alter the titin gene, take out pieces or add pieces to it, to mimic the mutations that we know exist in patients."
     
    Through these studies, the group discovered that the mutations that causes ARVC weakens the molecule, causing the "spring structure" to unfold. 
     
    "Normally the molecule folds into domains," Granzier said. "It resembles a string of pearls, and when you stretch the molecule, the pearls line up and you pull them taut. But if you have a mutation, it weakens the structure of the domains. The pearls unravel and once the molecule starts breaking down, the mechanical sensing ability is destroyed and the elasticity is messed up."
     
    Although therapies might not become available for a while, knowing what causes the trouble is a critically important first step, Granzier pointed out.
     
    Some day, therapeutics could be developed that interact with the weak spot in the mutated titin molecule and make it stronger. Another approach, currently tested for muscular dystrophy, involves drugs homing in on the machinery inside the cell that manufactures the protein from its genetic blueprint, instructing it to skip the mutated parts. 
     
    "Once we understand the sensing mechanisms of titin and how they are affected by mutations, we could ultimately come up with drugs that lessen the impact of the disease or prevent it altogether," Granzier said.
     
    Under the network grant, the collaboration will exchange expertise, reagents, genetically modified mouse models and researchers to maximize collaboration and results and tackle all aspects of these diseases. 
     
    "It is a huge honor for Henk and the UA to lead this international, multidisiplinary project from Fondation Leducq to decipher the impact of mutations in contractile proteins on human cardiac myopathies," said Carol Gregorio, who heads the Molecular Cardiovascular Research Program and is a collaborator on the grant. 
     
    In addition to the UA, the main research centers participating on the grant are the University of Heidelberg, Germany; University of California San Diego School of Medicine; National Heart & Lung Institute at the Imperial College London; the University of Liverpool; French biotech company Genethon; and the University of Pennsylvania School of Medicine. 
     

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  2. article (June 19) Today's Top Headlines - The top 10 stories of the day

    Wednesday, June 19, 2013 8:45 am

    1. OBAMA LAUNCHES PUSH FOR NUCLEAR WARHEAD CUTS

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  3. article ‘Man of Steel’ is an exciting reboot

    Wednesday, June 19, 2013 4:00 am

    There’s no denying that Richard Donner set the bar for the Superman franchise with his 1978 film. The icy landscapes of Planet Krypton, John Williams’ vigorous musical score, Christopher Reeve’s iconic performance - every aspect of Donner’s movie remains definitive.

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  4. article New Research Emerges For Parkinson's

    Tuesday, June 18, 2013 12:21 pm

    (NewsUSA) - People often believe the myth that Parkinson's disease only afflicts the elderly, but research indicates that a growing number of middle-aged adults are developing the neurodegenerative disorder. The National Parkinson Foundation reports that 10 percent of people with Parkinson's are diagnosed before age 40.

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  5. article AARP Arizona commends governor, legislators for Medicaid expansion

    Tuesday, June 18, 2013 10:05 am

    Flanked by a bipartisan coalition of lawmakers, and numerous stakeholders that included AARP Arizona, Governor Jan Brewer today signed historic legislation that will restore and expand Medicaid coverage for thousands of vulnerable Arizonans. 

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  6. article Avoiding Tick Dangers This Summer

    Tuesday, June 18, 2013 7:04 am

    (NewsUSA) - Tick-borne illnesses are found throughout the United States. Though Lyme disease, transmitted by blacklegged ticks, is the most pervasive and publicly discussed, the Centers for Disease Control and Prevention (CDC) lists a wide range of diseases spread by ticks. With tens of thousands of people impacted each year from such illnesses, the National Pest Management Association (NPMA) advises summer enthusiasts about the danger of disease transmission from ticks and encourages them to take proper precautions to protect against exposure to these blood-sucking pests.

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  7. article Guidance to help parents keep kids smoke-free

    Monday, June 17, 2013 5:00 pm

    Children often learn by example. They grow up watching Mom and Dad’s behaviors, learning at a very early age how to mimic their elders. In school, the examples shown by peers help to develop children, both academically and socially.

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  8. article Two-Time Super Bowl Champion Shines Spotlight on Diabetes Patients Who Give Back

    Sunday, June 16, 2013 5:00 pm

    (BPT) - Two-time Super Bowl Champion, Kendall Simmons, is one of almost 26 million people in the United States living with diabetes.[1] Diagnosed after his NFL rookie season in 2003, Kendall was in unfamiliar territory.

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  9. article Celebrate the dairy days of summer by keeping products cool and fresh

    Sunday, June 16, 2013 5:00 pm

    (BPT) - Nothing says summer like dairy products from the number one dairy state, California. From scoops of cold, creamy ice cream to melted cheese atop juicy grilled burgers, dairy and summer menus go together like sweet corn and butter. But nothing spoils the summer fun like spoiled milk, which is why it’s important to know how to store your dairy products – especially in the hotter months.

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  10. article One size doesn't fit all in reproductive health

    Sunday, June 16, 2013 5:00 pm

    (BPT) - Every woman knows that in the world of fashion, there’s no such thing as “one size fits all.” Yet for decades, American women have seemingly accepted the “one size fits all” approach when it comes to dealing with reproductive health issues. This one-size approach has meant that each year, thousands of women undergo hysterectomies that they may not need.

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  11. article How to Protect Your Family’s Skin from Summer’s Scrapes, Bites and Burns

    Saturday, June 15, 2013 2:15 pm

    Afternoons at the pool, family barbecues, outdoor sports and picnics all mean summertime has arrived. With the change in temperature comes additional exposure to the elements and the attendant skin scrapes, bites and burns.

  12. article (June 14) - Today's Top Headlines - Colorado fire kills two

    Friday, June 14, 2013 9:53 am

    Thousands of Colorado Springs residents remained poised for mandatory evacuation orders Friday as crews fought to prevent the most destructive wildfire in Colorado’s history from spreading inside the city limits.

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  13. article How to Protect Your Family’s Skin from Summer’s Scrapes, Bites and Burns

    Thursday, June 13, 2013 10:00 pm

    (StatePoint) Afternoons at the pool, family barbecues, outdoor sports and picnics all mean summertime has arrived. With the change in temperature comes additional exposure to the elements and the attendant skin scrapes, bites and burns.

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  14. article Don't let pests invade outdoor spaces

    Thursday, June 13, 2013 5:00 pm

    (BPT) - Most of us view lawns, porches, decks and gardens as extensions of our homes and look forward to enjoying these spaces during warm weather. Unfortunately, rising temperatures also bring invasive insects that can lay their claim to these spaces and cause hefty damage.

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  15. article (June 13) Today's Top Headlines - Top 10 stories for today

    Thursday, June 13, 2013 9:26 am

    1. SNOWDEN ACCUSES THE U.S. OF HACKING CHINA

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  16. article Care For Your Battery Today So It Can Care For You Later

    Thursday, June 13, 2013 4:44 am

    (NAPSI)—For many motorists, the battery is a case of under hood, out of mind until they’re stranded by a dead battery, which can be inconvenient and even dangerous—but this doesn’t have to happen to you. Look for such signs that the battery is failing as the headlamps look dim at idle and brighten when you rev the engine or the starter groans and turns slowly, barely starting the car.

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  17. article New Survey Reveals Busy Americans Fail To Prioritize Sleep

    Thursday, June 13, 2013 4:44 am

    (NAPSI)—Many Americans today struggle to get enough sleep. Despite their attempts to do it all, pressure to meet the demands of an active, on-the-go lifestyle may be holding men and women back from achieving the type of uninterrupted slumber that leaves them feeling rejuvenated in the morning. These issues are all too common, as the National Center on Sleep Disorders Research estimates that nearly 70 million Americans suffer from sleep problems.

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  18. article Clean-Up Tips to Get Your Backyard Ready for Outdoor Entertaining

    Wednesday, June 12, 2013 10:00 pm

    (StatePoint) After spending the cooler months neglected, backyards and patios get lots of use during the warmer months, when barbecuing and outdoor entertaining season is in full swing.

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  19. article How You Can Prevent Motion Sickness

    Wednesday, June 12, 2013 10:00 pm

    (StatePoint) Traveling this season? Whether your dream of the perfect vacation involves sandy beaches, long country drives, cobblestoned streets or endless vineyards, it probably doesn't include nausea.

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  20. How You Can Prevent Motion Sickness

  21. article Legislation would improve accuracy and efficiency while saving taxpayers money

    Wednesday, June 12, 2013 11:48 am

    Phoenix – With overwhelming bipartisan support from Arizona’s election community, legislation to correct issues that arose during the 2012 general election needs to be approved by the Legislature.

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  22. article As monsoons draw closer, ADOT emphasizes safe driving habits

    Wednesday, June 12, 2013 8:30 am

    The Arizona Department of Transportation has a message for motorists who think they can recklessly drive head-on into a dust storm: “Pull Aside, Stay Alive.”

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  23. article Racers Show Their Undies in Support of Colon Cancer Awareness

    Wednesday, June 12, 2013 8:03 am

    (NewsUSA) - Seven-time NASCAR champion Richard Petty has seen his fair share of races throughout his career. Yet, little could prepare him for the sight he'd see as nearly hundreds of people turned out for the Undy 5000 Track Walk benefitting the Colon Cancer Alliance (CCA).

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  24. article Spooked by Hurricanes, Homeowners Make Storm-Proofing Upgrades

    Wednesday, June 12, 2013 8:05 am

    (NewsUSA) - All those monster hurricanes and tornados we've been experiencing have apparently spooked homeowners worse than just about any disaster film Hollywood ever produced.

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  25. article Oro Valley, Marana to conduct employee market surveys

    Wednesday, June 12, 2013 4:00 am

    The towns of Oro Valley and Marana are each in the beginning stages of conducting employee market surveys that will compare the compensation of staff to surrounding communities – a process both municipalities hope will help with employee attraction and retention.

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