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May 23, 2013
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      Oro Valley Councilman Mike Zinkin is looking to clear his name after comments made earlier this month by Mayor Satish Hiremath regarding the c…

      • posted: May 22
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  1. article Three top tips for summer travel

    Wednesday, May 22, 2013 9:46 am

    As families nationwide are packing their gear and heading out by car, plane and boat, recent data suggests that this summer travel season could be substantially busier than in years past.

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  2. article Featured Community: Rancho Vistoso

    Wednesday, May 22, 2013 4:00 am

    Over the next several months we will be spotlighting various homes and subdivisions in Rancho Vistoso, but we thought we would kick things off with an overview.  

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  3. article Five steps to create a customized outdoor living space with railing

    Tuesday, May 21, 2013 5:00 pm

    (BPT) - Railing can upgrade any deck from drab to fab – adding style, as well as safety and support. In fact, it’s often the one element that truly sets your outdoor living space apart from others in the neighborhood. Here are five steps to create the perfect perimeter for your deck.

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  4. article Authors from across the U.S. coming to Pima Writers' Workshop

    Friday, May 17, 2013 3:30 pm

    Award-winning authors from across the country converge on Pima Community College later this month to inspire and encourage local writers at the 25thannual Pima Writers’ Workshop.

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  5. article Recognizing New Science Fiction Writers

    Wednesday, May 15, 2013 4:44 am

    (NAPSI)—There’s hopeful news for struggling writers. An annual contest is designed to encourage them and honor the best of their work. This year’s award ceremony was held at the Wilshire Ebell Theatre in Los Angeles, California.

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  6. article Three Top Tips for Summer Travel

    Tuesday, May 14, 2013 10:00 pm

    (StatePoint) As families nationwide are packing their gear and heading out by car, plane and boat, recent data suggests that this summer travel season could be substantially busier than in years past.  

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  7. article A Selection Of Books For Every Dad

    Thursday, May 9, 2013 4:44 am

    (NAPSI)—There’s good news for those who are tired of giving dad a new version of the same old tie for Father’s Day.

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  8. article Helping Cats And Dogs Have Healthy Joints

    Thursday, May 9, 2013 4:44 am

    (NAPSI)—Your four-footed friends could benefit from your taking four important steps to keep your pets in peak condition.

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  9. article Anthony Bourdain talks last meal on earth, advice for restaurateurs; old-school cocktails

    Wednesday, May 8, 2013 10:00 pm

    (BPT) - TV’s best-fed hedonist, Anthony Bourdain, is keeping busy these days with his hit travel series “Parts Unknown,” his publishing career and an upcoming appearance at this year’s National Restaurant Association Restaurant, Hotel-Motel Show in Chicago. Love him or hate him, Bourdain is the biggest, baddest food dude on the planet. The self-proclaimed “chef slacker” shares his advice for restaurateurs and new chefs, and talks about his desired last meal on Earth and love of old-school cocktails.

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  10. article What's Up UA? - UA Geneticists Find Causes for Severe Childhood Epilepsies

    Wednesday, May 8, 2013 5:09 pm

    Researchers at the University of Arizona have successfully determined the genetic mutations causing severe epilepsies in seven out of 10 children for whom the cause of the disorder could not be determined clinically or by conventional genetic testing.

    Instead of sequencing each gene one at a time, the team used a technique called whole-exome sequencing: Rather than combing through all of the roughly 3 billion base pairs of an individual's entire genome, whole-exome-sequencing deciphers only actual genes, and nearly all of them simultaneously.

    "My initial hope was that we would find something in one out of the 10 children in our study. But a 70 percent success rate is beyond anyone's imagination," said study leader Michael Hammer, who is a research scientist in the UA's Arizona Research Labs Division of Biotechnology and a member of the UA BIO5 Institute.
     
    For Hammer, the research hit very close to home. Just last year, his lab tracked down the mutation that had caused the severe – and ultimately fatal – epilepsy in his teenage daughter. 
     
    "I figured, if we could do this for one child, we could do it for others." Hammer explained. "These are children who have had every test imaginable and tried every possible drug combination, and nobody has figured out where their seizures come from and how to stop them."
     
    The children who participated in the study, published online in the journal Epilepsia, all suffered from severe seizure disorders, and most of them started having seizures within the first year or two after birth.
     
    Unlike individuals afflicted with epilepsy later in life, many of whom can live normal lives with the right medical oversight and medications, early-onset epilepsy can be devastating. Children often develop other severe complications such as intellectual disability, autism and loss of muscle tone or coordination. Early death is not uncommon.
     
    "Because their seizures are not well controlled, and that firestorm of electrical activity in the brain is bad for brain development, the damage can be extensive," added Linda Restifo, a professor in the UAdepartment of neurology and a BIO5 member who co-authored the study. "The earlier the seizures start and the more severe and frequent they are, the more likely they are to leave the child with permanent developmental disability."
     
    "The sooner we can catch problems in children and understand what is causing them, the better the chance we have to try and correct them," Hammer added. 
     
    To identify changes in the DNA that are the most likely cause of the disorders, the team focused on a class of mutations called de novo mutations: "typos" in the DNA sequence that are present only in the child. In order to find such mutations, the study included both parents and their child.
     
    Overall, the team found 15 mutations in nine children, seven of which are known or likely to cause epilepsy. No mutations could be found in one of the children. 
     
    "In four of the patients. we found mutations that were already known to be associated with epilepsy," said Krishna Veeramah, a postdoctoral fellow in Hammer's group and the study's first author. "However, three patients had mutations in genes that were not previously associated with epilepsy in humans but presented plausible explanations for the disorder."
     
    "The fact that we found three genes – in a study involving only 10 subjects – that had never been implicated in epilepsy before suggests that many more genetic defects related to developmental brain disorders remain to be discovered," Veeramah said.  
     
    One of the participants in the study was Ashley Wilhelm, a 14-year-old girl from Phoenix, Ariz., whose seizures started when she was only 5 months old. Her first seizures appeared to be triggered by fever, leading doctors to believe they were just that – a side effect of the fever. 
     
    "But she soon began to have more and more seizures, and they would last half an hour or longer," said her mother, Ann. "We had all sorts of tests done, but the doctors kept saying her brain was normal, and that they didn't see any reason she'd have those seizures."
     
    Ashley, whose development has severely suffered as a consequence of the repeated seizures, was enrolled in the study through her neurologist, Dinesh Talwar, who co-authored the paper.
     
    Even though her treatment is unlikely to change with the new information, the family said the results brought "more relief than we can explain."
     
    "Since insurance wouldn't pay for the testing, and we couldn't afford it on our own, we were very grateful we were able to participate in the study," said Jeff Wilhelm, Ashley's father. "If such a test could be done much earlier, it would ease the pain for everyone involved. What if our son had decided not to consider having children of his own out of concern they might have the disorder?"
     
    "The results from this study have at last given us a breakthrough," said the mother of another participating teenager. "We had pursued every possible avenue to understand what might be responsible for his epilepsy – magnetic resonance imaging, CT scans, searches for gross chromosome abnormalities or markers associated with epilepsy – with no success."
     
    "Although the discovery doesn't yet give us a treatment, it gives us hope for finding one," she said. "As more research is done on this mutation, drugs to control our son's seizures will be identified. If more children with epilepsy can be studied and families with children with similar mutations can organize and share resources, there will be more progress."
     
    Hammer said the approach is applicable to other conditions in which conventional genetic testing has failed to reveal the cause.
     
    "Our work bridges research and clinical practice," he added. "We can sequence all the genes in your genome in a matter of days and report it to the patient's family and the physician. That may make a difference in the treatment and management of the disorder in question."
     
    Centers with the capabilities to do this kind of analysis are few and far between.
     
    "Other centers that do this kind of work will sequence your genome and tell you where and what the mutation is in the DNA sequence, but it's not that simple," Hammer said. "In most cases, we find a mutation in a gene not previously known to cause disease, so we need to perform a follow-up study to find out what that mutation actually does."
     
    To perform these follow-up studies, the UA team has established collaborations with leading scientists at the UA and at other institutions.
     
    "Right now, the benefit to families is primarily to get answers," said Restifo. "The long-term goal is to collect this kind of information from more children, which will hopefully lead to new research into medications that improve brain development and function."
     
    Hammer added: "In the meantime, a molecular diagnosis provides immediate relief to the unnecessary guilt parents might feel for their role in causing their child's suffering. They want answers, not endless doctors visits and tests with negative results, or to have their hopes raised and dashed over and over."
     
    Encouraged by the success of their approach so far, Hammer and his colleagues already have bigger plans. 
     
    "We hope to involve other clinical areas such as cardiology, immunology, gastroenterology – anything that we can apply molecular diagnostics or clinical genomics to at the UA, we want to explore. We want to make the University the core for clinical diagnostics using new sequencing technologies for at least the entire Southwest."
     
    UA pediatric geneticist Robert Erickson, another co-author and member of the UA Steele Children's Research Center added, "these efforts will be very important in the diagnosis of newborns with unusual birth defects."
     

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  11. article Music and Accessory Trends For Today's Active Women

    Wednesday, May 8, 2013 9:54 am

    (NewsUSA) - Music and exercise have always complimented one another well, but fitness trends and research indicate real, quantifiable benefits.

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  12. article What can we really do (Part 2)

    Wednesday, May 8, 2013 4:00 am

    It was interesting to see the response The Explorer got last week after my editorial on what we citizens can really do to reach our elected officials. While I am deeply concerned with seemingly not having a voice unless we have enough money, I am not encouraging any residents to stop trying by any means. I still work to contact my elected officials and I always will, even if at times I feel it seems pointless.

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  13. article The ‘write’ way to cope with keeping a journal

    Wednesday, May 8, 2013 12:00 am

    Nineteenth century author Henry David Thoreau kept a journal of his reflections for the last 25 years of his life.

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  14. article What's Up UA? - UA Research Suggests Link Between Elevated Blood Sugar, Alzheimer's Risk

    Sunday, May 5, 2013 8:39 pm

    A new University of Arizona study, published in the journal Neurology, suggests a possible link between elevated blood sugar levels and risk for developing Alzheimer's disease.

    About 5 percent of men and women, ages 65 to 74, have Alzheimer's disease, and it is estimated that nearly half of those age 85 and older may have the disease, according to the U.S. Centers for Disease Control and Prevention. Among the known factors that contribute to the disease are age and genetics. Scientists also think that high blood pressure, high cholesterol and diabetes may increase risk.

    Although the link between diabetes and Alzheimer's has been studied, UA researchers wondered if elevated blood sugar levels in non-diabetic individuals also might indicate a higher risk for developing Alzheimer's disease.

    "There have been studies that have linked diabetes to Alzheimer's disease as a risk factor," said Alfred Kaszniak, UA professor of psychology and a co-author on the study. "What was not known when we began this work is whether that risk was only at levels of blood sugar that qualify for diagnoses of diabetes, or in the borderline or pre-diabetic range, or would we also see a relationship across the so-called normal range of blood glucose?"

    The researchers used fluorodeoxyglucose (18F) positron electron tomography, or FDG PET, a medical imaging technique that produces three-dimensional images of metabolic activity in the brain. Fasting serum glucose levels – blood sugar levels following several hours of not eating – are routinely acquired as part of the FDG PET protocol.

    "When compared to those without the disease, Alzheimer's disease patients demonstrate a pattern of reduced brain metabolism in particular brain regions," explained Christine Burns, lead author on the study and a UA pre-doctoral student in psychology. "What we show is an association between elevated fasting serum glucose levels and a similar pattern of reduced metabolism in these same AD-related brain regions in cognitively healthy adults."

    The researchers studied data on 124 cognitively normal, non-diabetic adults with a family history of Alzheimer's disease. The individuals, who ranged in age from 47 to 68, were among participants in a larger study, led by Dr. Eric Reiman, executive director of the Banner Alzheimer's Institute in Phoenix, looking at a variety of Alzheimer's risk factors, including genetic risk. 

    The link between high blood sugar and reduced brain metabolism existed regardless of whether individuals carried the Apolipoprotein E4 gene variant, an established risk factor for the development of Alzheimer's disease.   

    In addition to suggesting a link between elevated blood sugar levels and Alzheimer's risk in non-diabetic individuals, the study also shows promise for the use of brain imaging techniques like PET in identifying Alzheimer's risk and developing early preventative interventions, researchers say.

    "Right now, if you want to develop a drug or evaluate some other kind of a preventive measure for Alzheimer's disease, the labor and expense is prohibitive," Kaszniak said. "If you recruit people who may be at some risk, but are 20 years away from developing signs of the illness, what drug company or governmental agency is going to fund research that follows people for 20 years to see whether something is effective in prevention?

    "However, if you have a biologic marker, it suggests what areas you should really focus on in those very expensive longitudinal studies," he said.

    Burns said she hopes the findings will inform ongoing work designed to help develop early Alzheimer's interventions.

    "A lot of valuable research is focused on treatment and slowing decline in Alzheimer's patients," she said. "I'm interested in complementing this work with interventions that can be implemented earlier on, perhaps at middle age."

     

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  15. article U.S. Sen. John McCain visits Basis Oro Valley

    Thursday, May 2, 2013 5:10 pm

    U.S. Sen. John McCain, R – Ariz., visited Basis Oro Valley today to discuss issues affecting Arizonans and the nation.

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  16. article Are Women Better Leaders than Men?

    Wednesday, May 1, 2013 10:00 pm

    (StatePoint) With more women rising to top positions in business and government, the topic of women and their capacity for leadership has been all the buzz in the media lately.

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  17. article Aging-in-place upgrades that look great and make sense

    Tuesday, April 30, 2013 10:00 pm

    (BPT) - Do the words “aging in place” and “home improvement” conjure images of institutional-looking grab bars in bathrooms and overhead kitchen lights that could illuminate an airport runway? Many people eschew certain types of home improvements for the same reason others refuse to wear hearing aids – the negative connotations of age.

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  18. article Programming your child's health - 5 nutrition tips for baby's future health

    Sunday, April 28, 2013 10:00 pm

    (BPT) - What if you could program the future of your child’s health as simply as you program your alarm clock? Push a button, choose a selected wake-up time, click and you’re done. It’s not quite that simple, but studies show that what a woman eats just before and during pregnancy will impact the health of her child for the rest of his or her life. It’s an area of research called fetal programming.

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  19. article Laser spine surgery helps seniors find relief from lumbar spinal stenosis

    Tuesday, April 23, 2013 10:00 pm

    (BPT) - Two recent clinical studies bring good news to the aging population. If you have lower back pain, burning pain or numbness in your legs you are probably one of the many people suffering with Lumbar Spinal Stenosis (LSS) – a condition affecting a vast majority of the over-60 age group – and this good news applies to you.

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  20. article NBA GREAT WALTER DAVIS TEAMS UP WITH USPORTSHUB.COM AS HUB INSIDER

    Tuesday, April 23, 2013 8:44 am

    Denver, CO – (April 23, 2013) – UsportsHub.com, a Denver-based college sports startup announced today that former Phoenix Sun and six-time NBA All-Star Walter Davis has joined their player analysis team. In his role at UsportsHub.com, Davis will utilize this extensive experience to help supplement the already impressive roster of former college and NBA players that contribute content as Hub Insiders.

  21. article Teaching Children To Accept Others

    Sunday, April 21, 2013 10:00 pm

    (StatePoint) The world is changing and parents need to make sure their children are prepared to succeed in an increasingly globalized economy, say experts.

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  22. article Enseñando a los niños a aceptar a otros

    Sunday, April 21, 2013 10:00 pm

    (StatePoint) El mundo está cambiando y los padres deben asegurarse de que sus hijos estén preparados para triunfar en una economía cada vez más globalizada, dicen los expertos.

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  23. article Prevention, detection tips for the most common type of cancer

    Sunday, April 21, 2013 10:00 pm

    (BPT) - One in five Americans will get skin cancer in their lifetime, according to research published in the Journal of the American Medical Association. Melanoma, the most lethal form of skin cancer, has steadily increased over the past three decades – to the rate of one American dying an hour from it, according to the Skin Cancer Foundation. Detecting melanoma when it is most treatable is key to survival. Fortunately, you can take steps to reduce your risk of getting skin cancer, and improve your chances of catching it in its most curable stages.

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  24. article Breakthrough Research Reveals Pathway of Fibromyalgia

    Thursday, April 18, 2013 4:44 am

    (NAPSI)—For decades, debate has raged over whether fibromyalgia is a real medical disease. Despite the fact that fibromyalgia affects more than 12.3 million people in the United States—comparable to the number of people affected by cancer—some clinicians believe fibromyalgia is nothing more than a “syndrome.” When patients complain of chronic pain, diffuse muscle and joint tenderness, depression, mental fog, digestive troubles, severe fatigue, insomnia and other unbearable symptoms, they’ve often been told the problem is “in their heads.”

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  25. article The Guide -- Week of April 15

    Wednesday, April 17, 2013 4:00 am

    Century Theatres

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Sunshine School in Oro Valley read more

Sunshine School 9000 N. Oracle Road Tucson, AZ 85704, Suite 204 (520)742-6874 www.sunshineschooltucson.org/

Sunshine School in Oro Valley

Sunshine School 9000 N. Oracle Road Tucson, AZ 85704, Suite 204 (520)742-6874 www.sunshineschoolt...

Northwest Chatter

  • Marana Town Talk: Hot temperatures are here, don’t forget the pool

    Ed Honea, Special to The Explorer

    • icon posted: May 22
  • JTED is a helpful resource for students

    Thelma Grimes, The Explorer

    • icon posted: May 22
  • Such the Spot - The audacious pursuit of dreams

    Darcie Maranich/Special to The Explorer

    • icon Updated: May 19
  • Prime Time Review - 'Kitchen Nightmares' causes chaos for Scottsdale

    Logan Buus/Explorer Intern

    • icon posted: May 19

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Baby in stroller Falls Into Train Tracks Mom Jumps In Before Train Barrels In Caught On Camera read more

Baby in stroller Falls Into Train Tracks Mom Jumps In Before Train Barrels In Caught On Camera. A stroller carrying a 14-month-old girl rolled off a slanted train station platform and fell onto the tracks Wednesday, but the girl's mother leaped onto the tracks to rescue her with the help other passengers, transit officials said."What it looks like to us is that the mother became distracted by something, didn't apply the brake on the stroller and the stroller was able to move off the platform and onto the tracks," said Scott Sauer, director of system safety for the Southeastern Pennsylvania Transportation Authority. The accident happened Wednesday afternoon at the 56th Street station of the Market-Frankford Line in west Philadelphia. The platform at the station is slanted slightly for drainage purposes, Sauer said.Surveillance video shows a woman on the eastbound platform with the girl in a jogging stroller, which slowly rolls forward and topples over onto the tracks about 5 feet below. What initially appears to be the girl flying out of the stroller apparently was just a towel or a bag. The stroller comes to rest on the outer rail, which carries no charge. The woman is seen jumping down and lifting the girl to a man waiting on the platform. Other passengers ran to help, and one used an emergency call box to alert SEPTA police, who held an incoming train at the preceding stop.The infant was taken to Children's Hospital of Philadelphia for treatment of a cut on her forehead. Sauer said during a news conference that watching the video was "gut-wrenching.""With the stroller moving at such a slow rate of speed, you know, you want to call out to someone, `Hey, the stroller's moving! Somebody grab the stroller,'" Sauer said. He said the line is one of SEPTA's busiest, with trains running every six to 10 minutes. SEPTA police said no charges will be filed but the accident serves as a reminder for other riders to lock stroller brakes when waiting on platforms.

Baby in stroller Falls Into Train Tracks Mom Jumps In Before Train Barrels In Caught On Camera

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