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  1. article What's Up UA? - $6M Grant Boosts Molecular Heart Research

    Wednesday, June 19, 2013 1:00 pm

    A $6 million grant from Fondation Leducq, a French non-profit health research foundation fostering international efforts to combat cardiovascular disease, will boost an interdisciplinary, collaborative push to better understand how the heart deals with mechanical stress under healthy conditions and in the case of a defect. 
     
    Henk Granzier, a professor in the department of physiology and the Molecular Cardiovascular Research Program at the University of ArizonaCollege of Medicine, is one of two principal investigators leading the project, which was awarded as a transatlantic network grant, connecting scientists from seven institutions in Europe and the U.S. 
     
    "Many networks compete for this grant, and it is a great honor to be one of the very few that were selected for funding," said Granzier, who will oversee all projects, coordinate and communicate with the network collaborators and assist designing experiments, analyzing data and publishing scientific results. 
     
    The research endeavor revolves around titin, a protein that acts as a "molecular spring" and plays important roles in how muscle cells register mechanical stress (see UANews story, "UA Researcher Studies Protein's Link to Heart Disease"). Titin has moved into the spotlight of cardiovascular research once it was found that mutations in the titin gene are involved in many heart defects.
     
    "With this project, we want to try and understand the interplay between mechanical stress and heart disease, and how titin factors into all of that," said Granzier, who is also a member of the UA BIO5 Institute and holds the Allan and Alfie Norville Endowed Chair for Heart Disease in Women Research at the UA's Sarver Heart Center. 
     
    "You have billions of titin molecules in your heart, where they help it contract and expand," he said. "Titin is very important to make sure your heart doesn't expand too much or too little, so it doesn't overfill or under-fill with blood."
     
    But the molecule, which occurs not only in heart muscle but skeletal muscle as well, does much more than that. 
     
    "Titin acts as a sensor enabling a heart muscle cell to measure mechanical stress," Granzier explained. "When you lift weights, titin senses the added load and interacts with proteins that trigger signaling cascades, which in turn activate genes to crank out more muscle material, so your muscles become bulkier."
     
    Scientists hope that once they better understand the processes at a molecular level, they can develop therapies for conditions that are untreatable now. 
     
    "A big goal of this grant is to understand how mutations in titin cause pathological changes," Granzier said. "We'll focus largely on titin and all the proteins that interact with it. So far, we know of more than 20."
     
    For example, one particular mutation in the titin gene is known to cause a disease called ARVC, or arrhythmogenic right ventricular cardiomyopathy, an inherited heart muscle disorder where damaged heart muscle is gradually replaced by non-muscle tissue. 
     
    "This particular mutation makes titin more susceptible to breaking down," Granzier said. "Others truncate the protein so it loses pieces of its functionality."
     
    BIO5's Genetically Engineered Mouse Models (GEMM) Core, directed by Tom Doetschman, developed a mouse model allowing Granzier to study the mechanisms that underlie this disease. 
     
    "We genetically engineered this mutation to replicate the human disease in the mouse heart, and then we study the mouse to tease apart the disease mechanism under controlled conditions," Granzier said.
     
    A different series of genetic alterations in titin's DNA sequence was found to be the causal defect in about one third of individuals afflicted with a condition called dilated cardiomyopathy – another form of heart failure. Affected individuals frequently develop severe heart failure in their 30s or 40s.
     
    "We want to study this in this grant as well," said Granzier. "How do the mutations lead to the diseased heart?"
     
    To find answers, Granzier and his colleagues apply mouse genetics to eliminate certain titin-binding proteins and see how that changes the sensing and the enlargement of the heart.
     
    "What we want to know is, 'If you have a certain titin binding partner missing, how does the system respond and possibly cause diseases?'" Granzier said, adding that the six diseases that have so far been linked to titin are likely only the tip of an iceberg.
     
    "As more and more high-throughput sequencing technologies become available, my guess is we will find many more diseases that involve titin," he added. "And as awareness of these defects increases, it will become possible to screen family members for such mutations."
     
    Granzier's lab has established a worldwide reputation in titin research by studying the protein and its interactions at every scale, from the individual molecule to the entire heart.
     
    Using an atomic force microscope, the group can make measurements on single titin molecules.
     
    "We can measure characteristics like strength and elasticity of the molecule, and how those are affected by mutations in the titin gene," Ganzier explained. "We also study the mechanics of single cells isolated from the heart. And we can genetically alter the titin gene, take out pieces or add pieces to it, to mimic the mutations that we know exist in patients."
     
    Through these studies, the group discovered that the mutations that causes ARVC weakens the molecule, causing the "spring structure" to unfold. 
     
    "Normally the molecule folds into domains," Granzier said. "It resembles a string of pearls, and when you stretch the molecule, the pearls line up and you pull them taut. But if you have a mutation, it weakens the structure of the domains. The pearls unravel and once the molecule starts breaking down, the mechanical sensing ability is destroyed and the elasticity is messed up."
     
    Although therapies might not become available for a while, knowing what causes the trouble is a critically important first step, Granzier pointed out.
     
    Some day, therapeutics could be developed that interact with the weak spot in the mutated titin molecule and make it stronger. Another approach, currently tested for muscular dystrophy, involves drugs homing in on the machinery inside the cell that manufactures the protein from its genetic blueprint, instructing it to skip the mutated parts. 
     
    "Once we understand the sensing mechanisms of titin and how they are affected by mutations, we could ultimately come up with drugs that lessen the impact of the disease or prevent it altogether," Granzier said.
     
    Under the network grant, the collaboration will exchange expertise, reagents, genetically modified mouse models and researchers to maximize collaboration and results and tackle all aspects of these diseases. 
     
    "It is a huge honor for Henk and the UA to lead this international, multidisiplinary project from Fondation Leducq to decipher the impact of mutations in contractile proteins on human cardiac myopathies," said Carol Gregorio, who heads the Molecular Cardiovascular Research Program and is a collaborator on the grant. 
     
    In addition to the UA, the main research centers participating on the grant are the University of Heidelberg, Germany; University of California San Diego School of Medicine; National Heart & Lung Institute at the Imperial College London; the University of Liverpool; French biotech company Genethon; and the University of Pennsylvania School of Medicine. 
     

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  2. article What's Up UA? - Happy 90th Birthday, Steward Observatory

    Friday, June 14, 2013 12:33 pm

    "We have the best location of any educational institution in America. The University ought to make itself famous with a telescope."

    With those words, part of his long and persistent effort to bring a world-class observatory to the University of Arizona campus, pioneering astronomer Andrew Ellicott Douglass set forth his best argument.

    Arriving at the UA in 1906 from the Lowell Observatory outside Flagstaff, Douglass sought almost immediately to take advantage of Tucson's dry climate and clear night skies, using his renowned 1910 Halley's Comet observations as proof of the region's unique potential. As he wrote in a 1908 guest editorial in the Arizona Daily Star, "Nothing advertises a climate better than a big telescope."

    The paper's editors agreed: "The fame of its observatory would be greater than any other institution of like character in the United States. The atmospheric conditions are such as to demand recognition and consideration from the scientific men of all nations," according to a Feb. 6, 1910 editorial.

    Douglass unsuccessfully lobbied the state Legislature for funds but in 1916 secured a $60,000 donation, at first anonymously from Oracle resident Lavinia Steward, in memory of her late husband Henry B. Steward. Construction on Steward Observatory began that year, and on April 23, 1923, the UA formally dedicated the facility, with its state-of-the art 36-inch reflecting telescope at last making Tucson an astronomer's paradise.

    "Not only was this the first big donation (to the UA), it was the start of research at the University in a very real way," says Buell Jannuzi, current director of Steward Observatory and head of the astronomy department.

    From those ambitious beginnings – the Steward telescope was nicknamed the "All-American" because it was the first astronomical telescope built using all American-made products – the observatory and astronomy department have branched out in all directions, to radio, X-ray and ultraviolet astronomy, adaptive optics, space-based telescopes and the renowned Steward Observatory Mirror Laboratory, which constructs gigantic mirrors for the next generation of astronomy, the Large Synoptic Survey Telescope and the Giant Magellan Telescope.

    "Douglass wanted more than just a major telescope for the University of Arizona; he wanted Steward Observatory to produce discoveries and to share them with the world. I think he would agree that his successors have continued to develop the quality of research we're producing, using technological innovations not as the end points, but as tools to further scientific discovery," Jannuzi says. "Our aspirations are the same as those of Douglass; we are just pursuing them with more modern tools."

    Built on what was then the far east side of Tucson, Steward Observatory has been overtaken by campus expansion yet remains an iconic fixture of the UA, its white brick and dome now housing the 21-inch Raymond E. White Jr. Reflector telescope, used primarily for undergraduate education and public outreach, which has been a part of the observatory's mission since its dedication. The original 36-inch scope relocated to Kitt Peak in 1963 and remains in use by the Spacewatch Project.

    Leadership for Steward Observatory has maintained a remarkable continuity, with just seven directors over its 90 years, including Peter A. Strittmatter, who served 37 years as director and led a remarkable period of growth and development.

    "I think (Douglass) would agree the soul is still there in the observatory, and we're continuing the mission he set out for us," Jannuzi says, reflecting on what drew him to astronomy in the first place. "It's fun, like philosophers or theologians do, to think about the big questions. Often times we're working on some small part of a research project, but it's all part of a larger effort to understand the universe and how we relate to it."

     

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  3. article What's Up UA? - Supernova Discovered at UA SkyCenter

    Thursday, June 13, 2013 10:53 am

    Now you see it – now you don't. This, in a nutshell, describes how Adam Block, renowned astrophotographer and astronomy educator with the University of Arizona's Mt. Lemmon SkyCenter, discovered a supernova in a galaxy far, far away.

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  4. article What's Up UA? - Marks on Martian Dunes May Reveal Tracks of Dry-Ice Sleds

    Wednesday, June 12, 2013 11:41 am

    NASA research indicates that hunks of frozen carbon dioxide – or dry ice – may glide down some Martian sand dunes on cushions of gas similar to miniature hovercraft, plowing furrows as they go.
     
    Researchers deduced this process could explain one enigmatic class of gullies seen on Martian sand dunes by examining images from NASA's Mars Reconnaissance Orbiter, or MRO, and performing experiments on sand dunes in Utah and California.
     
    "I have always dreamed of going to Mars," said Serina Diniega, a planetary scientist at NASA's Jet Propulsion Laboratory, or JPL, in Pasadena, Calif., and lead author of a report published online by the journal Icarus. "Now I dream of snowboarding down a Martian sand dune on a block of dry ice."
     
    The hillside grooves on Mars, called linear gullies, show relatively constant width – up to a few yards or meters across – with raised banks or levees along the sides. Unlike gullies caused by water flows on Earth and possibly on Mars, they do not have aprons of debris at the downhill end of the gully. Instead, many have pits at the downhill end.
     
    "In debris flows, you have water carrying sediment downhill, and the material eroded from the top is carried to the bottom and deposited as a fan-shaped apron," said Diniega. "In the linear gullies, you're not transporting material. You're carving out a groove, pushing material to the sides."
     
    Images from MRO's High Resolution Imaging Science Experiment, or HiRISE, camera, operated by the University of Arizona, show sand dunes with linear gullies covered by carbon dioxide frost during the Martian winter. The location of the linear gullies is on dunes that spend the Martian winter covered by carbon dioxide frost. The grooves are formed during early spring, researchers determined by comparing before-and-after images from different seasons. Some images have even caught bright objects in the gullies.
     
    Scientists theorize the bright objects are pieces of dry ice that have broken away from points higher on the slope. According to the new hypothesis, the pits could result from the blocks of dry ice completely sublimating away into carbon-dioxide gas after they have stopped traveling.
     
    "Linear gullies don't look like gullies on Earth or other gullies on Mars, and this process wouldn't happen on Earth," said Diniega. "You don't get blocks of dry ice on Earth unless you go buy them."
     
    That is exactly what report co-author Candice Hansen, of the Planetary Science Institute in Tucson, Ariz., did. Hansen has studied other effects of seasonal carbon-dioxide ice on Mars, such as spider-shaped features that result from explosive release of carbon-dioxide gas trapped beneath a sheet of dry ice as the underside of the sheet thaws in spring. She suspected a role for dry ice in forming linear gullies, so she bought some slabs of dry ice at a supermarket and slid them down sand dunes.
     
    That day and in several later experiments, gaseous carbon dioxide from the thawing ice maintained a lubricating layer under the slab and also pushed sand aside into small levees as the slabs glided down even low-angle slopes.
     
    The outdoor tests did not simulate Martian temperature and pressure, but calculations indicate the dry ice would act similarly in early Martian spring where the linear gullies form. Although water ice, too, can sublimate directly to gas under some Martian conditions, it would stay frozen at the temperatures at which these gullies form, the researchers calculate.
     
    "We have seen blocks of ice sitting in the channels in our HiRISE images," said Alfred McEwen, a professor of planetary science at the UA who leads the HiRISE program who co-authored the paper. "Later, we saw them disappear by sublimation, in a matter of months."
     
    Although the HiRISE camera doesn't allow researchers to measure the blocks' composition directly, McEwen said they behaved in the right way for carbon dioxide ice.
     
    "Water ice block should be stable for much longer periods of time, and we know there is ample carbon dioxide in the area where those gullies are seen – in the higher latitudes of Mars' southern hemisphere."
     
    "The origin of these linear gullies has been a mystery," McEwen added. "This study provides some direct clues as to how they are forming. The experiments using the dry ice show that our hypothesis is plausible."
     
    Hansen also noted the process could be unique to the linear gullies described on Martian sand dunes.
     
    "There are a variety of different types of features on Mars that sometimes get lumped together as 'gullies,' but they are formed by different processes," she said. "Just because this dry-ice hypothesis looks like a good explanation for one type doesn't mean it applies to others."
     
    McEwen said the study adds an exciting new piece to growing series of discoveries about ongoing, active processes shaping the surface of the Red Planet. 
     
    "We are finding Mars is not Earth-like as it looks," he said. "Dry ice doesn't naturally exist here on Earth. MRO and the HiRISE instrument are healthy, and the longer the mission goes on, the longer we can observe and really understand these processes over the long term."
     
    McEwen said the team is planning to continue to monitor these sites to see more ice blocks in action.
     
    "We can't get any information from other instruments on the orbiter, because the features are too small," he explained. "But we are learning more about the distribution and latitude of those features and when they are active."
     
    The UA's Lunar and Planetary Laboratory operates the HiRISE camera, which was built by Ball Aerospace & Technologies Corp. of Boulder, Colo. JPL manages MRO for NASA's Science Mission Directorate in Washington. Lockheed Martin Space Systems of Denver built the orbiter.
     

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  5. article What's Up UA? - Astronomers Gear Up to Discover Earth-Like Planets

    Friday, June 7, 2013 12:05 pm

    If one looks only for the shiniest pennies in the fountain, chances are one misses most of the coins because they shimmer less brightly. This, in a nutshell, is the conundrum astronomers face when searching for Earth-like planets outside our solar system.
     
    Astronomers at the University of Arizona are part of an international team of exoplanets hunters developing new technology that would dramatically improve the odds of discovering planets with conditions suitable for life – such as having liquid water on the surface.
     
    The team presented its results at a scientific conference sponsored by the International Astronomical Union in Victoria, British Columbia.
     
    Terrestrial planets orbiting nearby stars often are concealed by vast clouds of dust enveloping the star and its system of planets. Our solar system, too, has a dust cloud, which consists mostly of debris left behind by clashing asteroids and exhaust spewing out of comets when they pass by the sun.
     
    "Current technology allows us to detect only the brightest clouds, those that are a few thousand times brighter than the one in our solar system," said Denis Defrère, a postdoctoral fellow in the UA'sdepartment of astronomy and instrument scientist of the Large Binocular Telescope Interferometer, or LBTI.
     
    He explained that while the brighter clouds are easier to see, their intense glare makes detecting putative Earth-like planets difficult, if not impossible. "We want to be able to detect fainter dust clouds, which would dramatically increase our chances of finding more of these planets."
     
    "If you see a dust cloud around a star, that's an indication of rocky debris, and it increases the likelihood of there being something Earth-like around that star," said Phil Hinz, an associate professor of astronomy at the UA's Steward Observatory. 
     
    "From previous observations, we know that these planets are fairly common," he added. "We can expect that if a space telescope dedicated to that mission were to look around a certain area of sky, we'd expect to find quite a few."
     
    Hinz and Defrère are working on an instrument that will allow astronomers to detect fainter clouds that are only about 10 times – instead of several thousand times – brighter than the one in our solar system. 
     
    "It's like being here in Victoria and trying to image a firefly circling a lighthouse in San Francisco that is shrouded in fog," Defrère said about the technological challenge. 
     
    "That level of sensitivity is the minimum we need for future space telescope missions that are to characterize Earth-like planets that can sustain liquid water on the surface," he explained. "Our goal is to eliminate the dust clouds that are too bright from the catalog of candidates because they are not promising targets to detect planets suitable for life."
     
    "With a bright dust cloud, which is 1,000 times brighter than the one in our solar system, its light becomes comparable to that of its star, which makes it easier to detect," explained Hinz. 
     
    Fainter clouds, on the other hand, can be about 10,000 times less bright than their star, so it becomes difficult or impossible for observers to make out their faint glow in the star's overpowering glare. 
     
    Funded by NASA, the team is in the middle of carrying out tests to demonstrate the feasibility of these observations using both apertures of the Large Binocular Telescope, or LBT, in Arizona. The project aims at determining how difficult it would be to achieve the desired results before committing to a billion-dollar space telescope mission. 
     
    According to Hinz, NASA's goal is to be able take a direct picture of Earth-like, rocky planets and record their spectrum of light to analyze their composition and characteristics such as temperature, presence of water and other parameters.
     
    "To do that, one would need a space telescope specifically designed for this type of imaging," he said. "Our goal is to do a feasibility study of whether it would be possible to distinguish the light emission of the planet from the background emission of the dust cloud through direct observation."
     
    The researchers take advantage of a technique known as nulling interferometry and the unique configuration of the LBT, which resembles a giant pair of binoculars. 
     
    "We combine the light from two apertures, cancel out the light from the central star, and with that it becomes easier to see the light from the dust cloud," Hinz explained. "To achieve this, we have to cause the two light paths to interfere with each other, which requires lining them up with very high precision. We'll always have some starlight left because of imperfections in the system, but our goal is to cancel it out to a level of 10,000 to get down to where we can at least detect the faint glow of the dust cloud."
     
    The work presented at the conference used the same technique with the two large telescopes of theKeck Observatory in Hawaii in order to detect the dust cloud around the star Fomalhaut located 25 light years from our sun. 
     
    "Based on our observations at the European Very Large Telescope Interferometer, we knew that Fomalhaut was surrounded by a bright dust cloud located very close to the star," said Jérémy Lebreton, principal investigator of the study, who is at the Institut de Planétologie et d'Astrophysique in Grenoble, France. 
     
    "Using the Keck Interferometer, we found out that Fomalhaut has a less bright, more diffuse cloud orbiting close to the habitable zone that resembles the Main Asteroid Belt in our solar system. This belt is likely in dynamical interaction with yet undetected planets."
     
    The study presented here is one in a series of three publications and was conducted in collaboration with the University of Amsterdam; the University of Liège in Belgium; NASA’s Jet Propulsion Laboratory at Caltech, Pasadena, Calif.; the University of Paris; and the University of Arizona in Tucson, Ariz. 
     
    Approximately 250 scientists from around the world convened at the scientific conference, Exploring the Formation and Evolution of Planetary Systems, held June 3-7 in Victoria to discuss the latest observations and theories about exoplanetary systems.
     

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  6. article What's Up UA? - Brigetta Barrett Named Pac-12 Woman of the Year

    Thursday, June 6, 2013 9:14 am

    The University of Arizona's Olympic silver medalist high jumper Brigetta Barrett has been named the Pac-12 Conference Woman of the Year for the 2012-13 academic year, Pac-12 Commissioner Larry Scott has announced.

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  7. article What's Up UA? - UA Classical Guitar Program Among World’s Best

    Wednesday, June 5, 2013 5:33 pm

    Chilean Master's student Pablo Gonzalez first picked up a classical guitar when he was 8 years old. The Spanish guitar stayed with him through his early education and finally swept him north to the University of Arizona as a Fulbright scholar, where he joined the roughly 25 undergraduate and graduate students in the UA's Bolton Guitar Studies Program.

    "You can find it in almost any home in my country," Gonzalez said of classical guitar music.

    Students in the UA program hail from countries around the world, including France, Chile, Philippines, China, Brazil, Peru, Mexico, Argentina, Norway, Turkey and many others, drawn by the reputation of a music program like no other.

    Many elements of the Bolton guitar program are found in no other classical guitar program in the world such as four endowed guitar competitions supported by the D'Addario string company and by donors, said professorR. Thomas Patterson, who heads the program.

    With boons such as artists in residence David Russell, a world-renowned musician and recording artist, and Grammy Award winners Sérgio and Odair Assad, it may not be surprising that UA classical guitar students regularly win at national and international guitar competitions.

    "The Assad Brothers come for a week in the fall, and David Russell comes for a week in the spring, and they teach for a week and give concerts," said Julia Pernet, chairman of the Tucson Guitar Society. "I think that's a very unusual asset to have, to have that class of performing guitarists come and spend a week, and really know the students."

    Patterson, who joined the UA faculty in 1980, is credited by many for making the guitar program what it is today. "I wanted to make it a flagship, a model for other programs around the country, around the world," Patterson said.

    "If you ask other guitar professors what are their greatest achievements, they say, 'Well, I published this book, or that book,'" said Misael Barraza, a first year Master's student in the program, who recently won theMontreal International Competition. "If you ask Tom, he'll say, 'See this guitar champion, or that champion? This was my student.'"

    "One of the great things that Tom is able to do is assist students to get to these international competitions and to try themselves out against the world," Pernet added.

    "We've seen people make extraordinary moves within our program," said Patterson. "It's exciting to see a high-end person achieve an international prize, but someone who maybe you're taking a risk with, to see them succeed is absolutely amazing."

    Pernet brings world-renowned performing artists to Tucson every year through the Tucson Guitar Society. "Part of the agreement that I sign with them is that they will give master classes for the UA guitar program," she said.

    In 2011, Sanford and Phyllis Bolton, lifelong music lovers and supporters of classical guitar, gave $2 million to establish the Sanford and Phyllis Bolton Endowed Chair for Classical Guitar, a position held by professor Patterson. Shortly after, Bolton gave an additional $1.1 million, establishing the Sanford and Phyllis Bolton Endowment for Guitar. 

    "This was the largest gift of its kind in the history of fine arts," Patterson said, a gift that has enabled the program to support talented students who otherwise may not be able to pursue their dreams with acoustic guitar. In honor of the support, the program changed its name to the Bolton Guitar Studies Program.

    The reputation of the program, its calendar packed with events and activities, and the supportive student community have attracted classical guitar talents from many nations. "I'm here because of the reputation of the guitar program," said Ivar Fojas, who is from the Philippines and also a Fulbright scholar, entering the third year of his doctoral studies.

    "Normally, other guitar programs would have one or two recitals each semester," Fojas said. "We have them every single week. I've learned how to listen, to really be critical of myself."

    "That's really what makes the difference between players," Barraza added. "Is how well you can listen to yourself."

    The guitar program curriculum engages students in the community, with a public performance every Friday at 11 a.m. in the UA Museum of Art, and many other concerts and recitals throughout the year.

    Patterson said he also makes effort to engage the community through concerts and working with children, to get them involved with guitar and music at a young age.

    "It really pushes you to have higher standards for yourself," said Leandra Hubka, who is finishing her Master's degree. "There are so many opportunities to play for the public," she added. "You get better by playing for people."

    Barraza said he aims for a concert career, and that the UA guitar program has "been a huge influence on me. I wouldn't be able to do without it."

    "We have an enormously supportive group of people," Patterson said. "I have friends who have traveled all over the world; I ask them if this happens anywhere else, and they say no."

    "We have four in-house competitions each year," Hubka said. "It would be really easy to get competitive with each other, but we're not at all." Perhaps competition is out of the question among a group of people unified by the sound of an instrument they can't put down.

    "It has that effect sometimes," Barraza mused. "The guitar just grabs onto you, and that's it."

     

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  8. article Morgan ready for no-nonsense coaching for UA

    Sunday, June 2, 2013 12:42 pm

    R.J. Morgan reports to Arizona on June 23 but he is not leaving the state of Oregon alone.

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  9. article Tucson–Joe Bourne Returns to local church

    Friday, May 31, 2013 10:45 am

    Back by popular demand, popular local jazz artist has appeared with The Stylistics, Natalie Cole, The Pointer Sisters, and Dionne Warwick, and will present a free jazz concert in NW Tucson on Saturday, June 15, 7-9 pm.

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  10. article Pet News - Free adult cats in June for national Adopt-a-Shelter-Cat Month

    Thursday, May 30, 2013 10:00 am

    Every year about this time, the cat adoption room at Pima Animal Care Center is flooded with kittens, leaving lots of kitties in need of new homes. 

  11. article What's Up UA? - The New Face of Mining: Women Carving Out a Place in Surging Industry

    Wednesday, May 29, 2013 1:06 pm

    They roam the remotest corners of the world, scale the highest mountains and descend deep into the Earth.

  12. article Happenings: Week of May 26

    Wednesday, May 29, 2013 4:00 am

    THEATER 

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  13. UA football

  14. article Experience will be weighed in Arizona quarterback battle

    Tuesday, May 28, 2013 11:09 am

    When Anu Solomon joins Arizona's quarterback competition in fall camp, he will have less than a month to impress the coaching staff enough to win the starting job.

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  15. article What's Up UA? - Three UA Students Named Tillman Military Scholars

    Friday, May 24, 2013 2:27 pm

    Joining military veterans and their spouses from across the nation, three University of Arizona students have been named to the fifth class of Tillman Military Scholars.

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  16. article What's Up UA? - Student EMTs Give Rapid Response to Campus Emergencies

    Wednesday, May 22, 2013 11:43 pm

    Whether it's a bicycle collision or difficulty breathing, the UA community can count on quick help from students trained and certified as EMTs.
     
    The University of Arizona Student Emergency Medical Services, or UASEMS, group has been operational for three semesters and provides assistance in medical emergencies. Its leaders emphasize thorough training and certification.
     
    "We're students at the UA who happen to be EMTs. We're not student EMTs," says Derek Smith, manager of UA Student Emergency Medical Services and a non-degree-seeking graduate student.
     
    When Brandon Murphy arrived at the UA three years ago, he didn't find any options for students to work in EMS on campus. He met up with two other students – who've since graduated – to begin brainstorming a program that students could run. They looked at other universities that have student EMS programs and modeled a club after the best practices they found around the country. It took two years to work through the administration and risk management officials, but they were able to start as a club with ASUA funding and began responding in spring 2012.
     
    UASEMS switched to funding from the student service fee and began expanding hours in fall 2012. As the fall progressed, the group did too, taking on additional days until they were operating from 6 p.m. to 6 a.m. seven days a week.
     
    UASEMS this year was the sole EMS provider at the Tucson Festival of Books, saving the festival $4,000 by not using the Tucson Fire Department. UASEMS also works stand-by at Spring Fling, football games and tailgating and when requested for special events, like the Susan G. Komen Race For The Cure.
     
    "Anything that occurs on campus, we can be there," Murphy says. "Our members do get put into emergencies where they're the only person there, so we make sure they're held to the same certification. We weren't going to settle for a CPR certification or anything else. We make sure everyone has state certification."
     
    UASEMS finished the semester with 32 student members, most of whom are certified Emergency Medical Technicians, with the same Arizona training and certification as a Southwest Basic Life Support Ambulance. Two EMTs staff each 12-hour shift, sometimes along with an additional Certified First Responder, and typically respond to at least two calls for service. On its busiest day, UASEMS responded to 12 calls in a 24-hour period.
     
    Common calls for service deal with fall victims, injuries from pedestrian, bicycle or vehicle collisions and respiratory distress.
     
    "It's part of our emergency mission to provide a quick, rapid response and be the first to provide care until further medical care arrives," Murphy says.
     
    By checking vital signs and reporting to paramedics, the student EMTs can eliminate a step and save valuable time if a patient needs to be taken to a hospital.
     
    "There are calls where we take the blood pressure while waiting for TFD and give the information right to them so they can load and go. They appreciate it," Murphy says.
     
    Many students join out of an interest in a future medical career, some have even gone on to medical school already, while others are considering EMT as a career. Interest is growing; the group has received 80 applications since the fall that they haven't been able to accept. They're hoping to take on as many as 10 in the fall and hope to expand to providing EMS service around the clock, seven days as week.
     
    UASEMS has a golf cart and two bicycles, all equipped with emergency gear. UAPD ride-alongs are a mandatory part of the orientation, which includes 20 hours of vigorous bike training and instruction on bloodborne pathogens and health privacy laws. The members participate in monthly continuing education courses and perform mock drills during the week.
     
    "It's real-life, in-the-field experience they can't get shadowing somebody in a hospital," says Murphy, a junior in communications from New Jersey. "Here, you're set to a standard and you have a responsibility. That is your patient until further medical attention arrives."

     

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  17. article The Guide -- Week of May 22

    Wednesday, May 22, 2013 4:00 am

    Century Theatres

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  18. article UA Basketball - Stoudamire prefers college over coaching pros

    Monday, May 20, 2013 2:36 pm

    There was a time when Xavier Henry was a top-10 recruit before starring at Kansas. The Memphis Grizzlies then made him the 12th overall selection in the 2010 NBA draft after just one season in the college ranks.

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  19. article What's Up UA? - UA Ranks Second in U.S. for Peace Corps Coverdell Fellows

    Friday, May 17, 2013 12:54 pm

    Thanks to the service-oriented nature of the University of Arizona community, the institution has for years been one of the nation's top-raking producers of Peace Corps volunteers.

    And that's not all. The UA also ranked second on the newly released Peace Corps' 2013 list of top Paul D. Coverdell Fellows programs, which are administered at institutions across the nation.

    For Peace Corps volunteers returning to the U.S. states, the Coverdell Fellows program provides them with scholarships, academic credit and other support toward a graduate degree. In addition to their studies, fellows are able to complete internships in underserved communities in the U.S.

    "The University of Arizona has established an impressive record of top rankings in the Paul D. Coverdell Fellows program,” Janet Allen, the Peace Corps West Coast regional manager, said in a prepared release.

    Today, 52 returned Peace Corps volunteers are enrolled in the UA's 12-year-old Coverdell Fellows program. Since 2001, 159 UA students have completed the program.

    "I had the honor of meeting this year's Fellows cadre during the UA's Peace Corps Week," Allen also noted. "They bring an impressive wealth of Peace Corps experience to their graduate work and a strong service ethic to the UA and the greater Tucson community – it's a win for everyone."

    Other institutions that made the top producing list for the Coverdell Fellows programs include the University of Denver, Johns Hopkins University and Brandeis University.

    "Every year, hundreds of Peace Corps volunteers make a difference by combining meaningful service with graduate studies through Peace Corps' Master's International and Coverdell Fellows programs," Peace Corps Deputy Director Carrie Hessler-Radelet said in a statement.

    "After completing Peace Corps service, volunteers return to the United States as global citizens, with leadership, cross-cultural understanding and language and technical skills that position them for success in today's global job market," Hessler-Radelet also noted.

    Since 1961, a total of 1,147 UA alumni have served in the Peace Corps, with 41 currently serving overseas.

    Holly Bryant, who served as a community health volunteer before becoming a fellow at the UA, said her classroom-based education was greatly reinforced through her service work.

    "This allowed me to test the limits of my comfort zones and my knowledge as it is applied in the real world," said Bryant, a student in the UA Mel and Enid Zuckerman College of Public Health.

    "Flexibility is the key, being able to move with the flow of what's happening in the moment," said Bryant, who served in Uganda from 2008 to 2010. "These traits were integral during my Peace Corps service."

     

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  20. article What's Up UA? - Eller College to Bring MBA Program Online

    Thursday, May 16, 2013 11:12 am

    The University of Arizona Eller College of Management's internationally recognized MBA program will be available online beginning this fall. Applications for the program now are being accepted.

    "Business schools need to be responsive to the changing needs of their students, and we are committed to offering many modes of graduate business education," said Len Jessup, dean of the Eller College. "Making the MBA program more flexible for highly qualified students is part of our broader effort to expand access to the University of Arizona and will go a long way toward increasing its footprint in Arizona and beyond."

    Hope Schau, associate dean of Eller MBA programs, added, "Offering our program in an online format opens it up to a new segment of students. We pride ourselves on meeting the needs of highly qualified students at all stages of their careers, and this new offering reflects that commitment."

    With a focus on innovation, application and communication, the Eller MBA experience is designed to give graduates what they need to effectively lead in today's changing global marketplace. Like its full-time, evening and executive MBA formats, the Eller online MBA program is fully accredited by the International Association for Management Education.

    The UA has chosen Academic Partnerships, or AP, one of the largest representatives of public universities' online learning in the United States, to help convert the program into an online format, recruit students and support student retention efforts. AP will work closely with Eller faculty to ensure that the new online degree program maintains the highest educational standards.

    The company also will use its integrated marketing and branding strategies to extend the University's reach, increasing the enrollment of highly qualified students.

    The UA's new online MBA program will begin in September 2013. Click here to apply or learn more about the program.
     
    The Eller College is internationally recognized for pioneering research, innovative curriculum, distinguished faculty, excellence in management information systems, entrepreneurship and social responsibility. U.S. News & World Report ranks the Eller undergraduate program No. 14 among public business schools and three of its programs are among the top 20 – entrepreneurship, MIS and management. 

    U.S. News & World Report ranks the Eller MBA full-time program No. 44 in the U.S. and No. 21 among public business schools. The college leads the nation's business schools in generating grant funds for research.

    In addition to a full-time MBA program, the Eller College offers an evening MBA program and the Eller Executive MBA. The Eller College supports approximately 5,700 undergraduate and 700 graduate students on the UA campus.

    Academic Partnerships helps universities convert their traditional degree programs into an online format, recruits qualified students and supports enrolled students through graduation. Serving more than 40 public institutions, AP is one of the largest representatives of public universities' online learning in the United States. 

    The company was founded by social entrepreneur Randy Best, an 18-year veteran of developing innovative learning solutions to improve education. AP is guided by the principle that the opportunities presented through distance learning make higher education more accessible and achievable for students in the U.S. and globally.

     

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  21. article The Guide -- Week of May 15

    Wednesday, May 15, 2013 4:00 am

    Century Theatres

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  22. article 'Visual Expressions of Voice' Exhibition

    Sunday, May 12, 2013 11:00 pm

    Between September and December 2012, a group of 86 talented and critically engaged sixth-grade students from Alice Vail Middle School investigated the ways in which visual culture informs our perceptions of gender, the persuasive power of ecological art, and the reflective nature of art making. This exhibition validates and honors the voices of these students and the power of art integration.  

    Opening reception from 3-4:30 p.m. May 15.

  23. article What's Up UA? - UA Offers Continued Career Support for New Grads Entering Workforce

    Saturday, May 11, 2013 11:37 am

    This weekend, thousands of newly minted University of Arizona alumni will wake up and face the question before all new college graduates: What's next?

    For some, the answer is already known. To date, 26 percent of respondents to UA Career Services' annual "career destinations" survey of graduating seniors say they have already secured full-time, post-graduation employment in their field. Another 17 percent say they have been accepted into graduate school.

    For those who still aren't quite sure what the future holds, help is available from their alma mater.

    "Graduating students still have access to all the resources Career Services has to offer," said Eileen McGarry, director of UA Career Services. "That includes a rich, very robust Web suite of resources and events."

    For just $20 a year, UA grads can continue to access a variety of Career Services resources, including online job postings, career fairs, seminars, one-on-one career counseling, the opportunity to participate in on-campus interviews with select employers and more. For members of the UA Alumni Association, Career Services access is included in membership.

    "If students haven't started looking for jobs or haven't had the success they wanted, there still is a lot to tap into," McGarry said. "Our staff offers career counseling by appointment. They also offer walk-in advice to help get that resume sharpened, help you enhance interview skills and learn how to reach market segments."

    Career Services begins working with UA students early in their academic careers to connect them with valuable internship, research, leadership and employment opportunities.

    In the 2012-13 academic year, the number of student internships posted online on the Career Services' Wildcat Joblink website jumped 90 percent from last year, with 2,100 opportunities targeting UA students. Meanwhile, full-time positions posted for students grew 20 percent to 3,100. In addition, University career fairs brought in 620 companies, while more than 210 employers engaged in active employee recruiting on campus, interviewing more than 3,600 students. 

    McGarry notes that although the job market is improving for college graduates, it remains competitive.

    Recent surveys by the National Association of Colleges and Employers, or NACE, suggest that employers plan to hire just 2.1 percent more new college grads from the class of 2013 than they hired from the class of 2012, with the top five hiring industries being educational services; professional, scientific and technical services; health care; federal, state and local government; and finance and insurance. The most in-demand graduates, nationally, include those with engineering, computer science, accounting and business degrees.

    As students prepare to enter this competitive workforce, there are a few things they should remember in addition to tapping into Career Services resources, McGarry says.

    No. 1: Be patient.

    "Sometimes, depending on a student's experience, they have to start in a position they might not have envisioned was what they were going to do doing when they graduated, and then they grow from there," McGarry said. "But anytime I've seen graduates move in, they quickly move up because they're valued by employers, and that often propels them into leadership roles quickly."

    Employer satisfaction surveys of companies that recruit from the UA show overwhelming satisfaction with UA graduates hired, especially with regard to their teamwork, communication and problem solving skills, McGarry said.

    Also important for job seekers is face-to-face networking. McGarry says students should stay in touch with contacts like professors and UA staff as well as seek out new connections through professional networks related to their field or through UA Alumni Association chapters in their part of the country.

    In today's digitally connected world, online networking also is essential. McGarry advises job seekers create a LinkedIn profile to highlight their professional accomplishments and connect with others in their field online. They also should be mindful of how they represent themselves on social networking platforms, such as Facebook, considering how information they share publicly might be viewed by a potential employer.

    Of course, a good resume remains forever important. McGarry reminds students their resume should not just describe their past experiences, but rather highlight their specific accomplishments and how what they did had a qualitative or quantitative impact.

    When it comes to actually interviewing for a job, candidates should be able to reflect in meaningful ways on their prior experiences and come prepared with a solid understanding of the company interviewing them. McGarry also advises following up with potential employers with "gentle persistence."

    Finally, for graduates who have already landed a job, it's important to engage fully in the workplace culture while maintaining a long-term view, McGarry advises.

    "Really tune into the culture and really listen to those that want to mentor you," she said. "Start with a mindset that you're really going to be committed to the environment and take a lot in. You also want to keep a long-term view, always – looking out further and having a long-term perspective in mind, not just what's happening right now."

     

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  24. article What's Up UA? - UA Geneticists Find Causes for Severe Childhood Epilepsies

    Wednesday, May 8, 2013 5:09 pm

    Researchers at the University of Arizona have successfully determined the genetic mutations causing severe epilepsies in seven out of 10 children for whom the cause of the disorder could not be determined clinically or by conventional genetic testing.

    Instead of sequencing each gene one at a time, the team used a technique called whole-exome sequencing: Rather than combing through all of the roughly 3 billion base pairs of an individual's entire genome, whole-exome-sequencing deciphers only actual genes, and nearly all of them simultaneously.

    "My initial hope was that we would find something in one out of the 10 children in our study. But a 70 percent success rate is beyond anyone's imagination," said study leader Michael Hammer, who is a research scientist in the UA's Arizona Research Labs Division of Biotechnology and a member of the UA BIO5 Institute.
     
    For Hammer, the research hit very close to home. Just last year, his lab tracked down the mutation that had caused the severe – and ultimately fatal – epilepsy in his teenage daughter. 
     
    "I figured, if we could do this for one child, we could do it for others." Hammer explained. "These are children who have had every test imaginable and tried every possible drug combination, and nobody has figured out where their seizures come from and how to stop them."
     
    The children who participated in the study, published online in the journal Epilepsia, all suffered from severe seizure disorders, and most of them started having seizures within the first year or two after birth.
     
    Unlike individuals afflicted with epilepsy later in life, many of whom can live normal lives with the right medical oversight and medications, early-onset epilepsy can be devastating. Children often develop other severe complications such as intellectual disability, autism and loss of muscle tone or coordination. Early death is not uncommon.
     
    "Because their seizures are not well controlled, and that firestorm of electrical activity in the brain is bad for brain development, the damage can be extensive," added Linda Restifo, a professor in the UAdepartment of neurology and a BIO5 member who co-authored the study. "The earlier the seizures start and the more severe and frequent they are, the more likely they are to leave the child with permanent developmental disability."
     
    "The sooner we can catch problems in children and understand what is causing them, the better the chance we have to try and correct them," Hammer added. 
     
    To identify changes in the DNA that are the most likely cause of the disorders, the team focused on a class of mutations called de novo mutations: "typos" in the DNA sequence that are present only in the child. In order to find such mutations, the study included both parents and their child.
     
    Overall, the team found 15 mutations in nine children, seven of which are known or likely to cause epilepsy. No mutations could be found in one of the children. 
     
    "In four of the patients. we found mutations that were already known to be associated with epilepsy," said Krishna Veeramah, a postdoctoral fellow in Hammer's group and the study's first author. "However, three patients had mutations in genes that were not previously associated with epilepsy in humans but presented plausible explanations for the disorder."
     
    "The fact that we found three genes – in a study involving only 10 subjects – that had never been implicated in epilepsy before suggests that many more genetic defects related to developmental brain disorders remain to be discovered," Veeramah said.  
     
    One of the participants in the study was Ashley Wilhelm, a 14-year-old girl from Phoenix, Ariz., whose seizures started when she was only 5 months old. Her first seizures appeared to be triggered by fever, leading doctors to believe they were just that – a side effect of the fever. 
     
    "But she soon began to have more and more seizures, and they would last half an hour or longer," said her mother, Ann. "We had all sorts of tests done, but the doctors kept saying her brain was normal, and that they didn't see any reason she'd have those seizures."
     
    Ashley, whose development has severely suffered as a consequence of the repeated seizures, was enrolled in the study through her neurologist, Dinesh Talwar, who co-authored the paper.
     
    Even though her treatment is unlikely to change with the new information, the family said the results brought "more relief than we can explain."
     
    "Since insurance wouldn't pay for the testing, and we couldn't afford it on our own, we were very grateful we were able to participate in the study," said Jeff Wilhelm, Ashley's father. "If such a test could be done much earlier, it would ease the pain for everyone involved. What if our son had decided not to consider having children of his own out of concern they might have the disorder?"
     
    "The results from this study have at last given us a breakthrough," said the mother of another participating teenager. "We had pursued every possible avenue to understand what might be responsible for his epilepsy – magnetic resonance imaging, CT scans, searches for gross chromosome abnormalities or markers associated with epilepsy – with no success."
     
    "Although the discovery doesn't yet give us a treatment, it gives us hope for finding one," she said. "As more research is done on this mutation, drugs to control our son's seizures will be identified. If more children with epilepsy can be studied and families with children with similar mutations can organize and share resources, there will be more progress."
     
    Hammer said the approach is applicable to other conditions in which conventional genetic testing has failed to reveal the cause.
     
    "Our work bridges research and clinical practice," he added. "We can sequence all the genes in your genome in a matter of days and report it to the patient's family and the physician. That may make a difference in the treatment and management of the disorder in question."
     
    Centers with the capabilities to do this kind of analysis are few and far between.
     
    "Other centers that do this kind of work will sequence your genome and tell you where and what the mutation is in the DNA sequence, but it's not that simple," Hammer said. "In most cases, we find a mutation in a gene not previously known to cause disease, so we need to perform a follow-up study to find out what that mutation actually does."
     
    To perform these follow-up studies, the UA team has established collaborations with leading scientists at the UA and at other institutions.
     
    "Right now, the benefit to families is primarily to get answers," said Restifo. "The long-term goal is to collect this kind of information from more children, which will hopefully lead to new research into medications that improve brain development and function."
     
    Hammer added: "In the meantime, a molecular diagnosis provides immediate relief to the unnecessary guilt parents might feel for their role in causing their child's suffering. They want answers, not endless doctors visits and tests with negative results, or to have their hopes raised and dashed over and over."
     
    Encouraged by the success of their approach so far, Hammer and his colleagues already have bigger plans. 
     
    "We hope to involve other clinical areas such as cardiology, immunology, gastroenterology – anything that we can apply molecular diagnostics or clinical genomics to at the UA, we want to explore. We want to make the University the core for clinical diagnostics using new sequencing technologies for at least the entire Southwest."
     
    UA pediatric geneticist Robert Erickson, another co-author and member of the UA Steele Children's Research Center added, "these efforts will be very important in the diagnosis of newborns with unusual birth defects."
     

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  25. article The Guide -- Week of May 8

    Wednesday, May 8, 2013 4:00 am

    Century Theatres

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